15 Machines in The Capsule Filling Line: From Raw to Final

What machines are mainly involved from powder to final capsule filling? In the modern world, capsule medication is significantly popular. The answer to its high demand is yet its convenience, patient compliance, and taste-masking properties.

Capsule

Picture Courtesy: Farm and Dairy

However, it is quite suitable to keep your active ingredient pretty safe from the harsh environment of the digestive system. When it comes to capsule filling, there’s no doubt an encapsulation offers a significant role and ensures that an accurate and correct capsule is formed. But when you’re thinking from the very scratch, then there are ‘15 machines in the capsule filling line: from raw to final’ that are described in this post.

Picture courtesy: European Pharmaceutical Manufacturer

For capsule filling, you cannot directly fill raw or coarse granules into it! You must consider the characteristics of the materials to be filled to avoid capsule defects and the potency of the medication. The granules or powder inside the capsule is generally of smaller size which is mostly estimated as to be 30 mesh or 600 microns. Moreover, the filling capsule has other recommendations too to bring a quality product without any problems. Look at the step-by-step involvement of machines included in the capsule filling line.

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1.Cone Mil

Cone Mil- Picture Courtesy: Pharmaceutical processing and packing machinery

This is the first step when you’re processing the capsule filling procedure. Cone mil which is also known as conical mil, or co-mil plays a primary role in the reduction of particle sizes of raw powder or raw materials for encapsulation.

If you open a capsule, you can see uniform size particles, this is mainly done by consistently applying an impact force to make them uniform thus making them homogenous and better flowability ratio. It helps in good mixing and further processing of ingredients.

Working Principle

Cone Mil- Picture Courtesy: Quadra Engineering

Machine working begins with the feeding of raw powder inside the feeder and by application of force the material grounds between the mill wall and impeller. It is generally estimated that the size reduction can be achieved as small as 10 microns. The desirable size materials can be screened by the machine and discharged out. Various available cone mills are offering self-cleaning and reduced risk of cross-contamination.

2.Granulator

This is the second machine used in the capsule filling line to improve the flow properties of the milled particles produced from the cone mill machine known as a granulator. In easier words, in a capsule, you can see the smooth and even shape of each particle which is commonly achieved by granulation. For this reason, a granulator is used. There are two types of granulation processes- dry granulation and wet granulation- that can be attained by dry and wet granulators.

Working Principle

The working principles of dry and wet granulators are described below:

Dry Granulator

Allpack Dry Granulator

In this step, a roller compressor is used. Dry granulation involves slugging or mechanical compression of rollers to form an agglomeration of powders.

The dry powder is added into the machine and blended by application of high force over it to form a considerable ratio of enlarged particles. In this procedure, a compact layer is a product which is also known as a ribbon or flake.

Wet Granulator

Allpack Swing Granulator

Here the machines used are known as a high shear mixer granulator and fluid bed wet granulator machine.

A wet granulation as its name shows involves binder incorporation of wet mass or adhesion. The overall purpose of using this technique is to obtain uniform characteristics and sizes of particles for the final manufacturing of the product.

The primary steps used in the wet granulation is involved as wetting followed by nucleation, binder, consolidation & growth, attrition, and final breaking.

3.Sifter

Sifter powder for capsule- picture courtesy: Manufacturing chemist

A sifter or powder sieving machine is used to separate and grade the powder particles and prevent them from lumping by the screening process. It is used to produce a refined raw material and ensure promising homogeneity of powder with enhanced quality of flow ratio. Once it is achieved by the application of a sifter or sieving machine, you can now use them for filling capsules with accurate dosage and a maintained batch-to-batch quality. There are various types of sifters such as rotary centrifugal, and vibratory sifters that are mainly selected on your application type and batch size.

Working Principle

Allpack Sifter

First, we will talk about the centrifugal or rotary sifter machine that mainly follows the working principle based on centrifugation. The following force is mainly used to separate and grade the particles depending upon variation in sizes. also, it is helpful in the de-agglomeration of particles by excessive spinning caused by the paddles of the machine.

The second machine working is based on vibratory forces where a gyratory motion allows the particles to sieve respectively on different meshes. The smaller-sized particles are screened vi passing from sieves while the larger particles remain over the screen and ensure uniform and same-size particles are filled in the capsules.

4.Mixer

Mixer

Medicinal powders- Picture Courtesy: Kerone

The mixer plays a pivotal role in the mixing of active and excipients such as additives, fillers, glidants, etc., to form a complete formulation to be subjected as a filling material in the capsule with accurate ratio and proper blending in every batch produced by your production line.

There are various types of mixers used in pharmaceutical companies in the capsule filling line such as a ribbon mixer, bin blenders, tumbler mixers, high shear mixers, etc., the mixer is important to install as it helps in the fast and safe mixing process without worrying about cross-contamination or developing drug resistance when manufacturing or filling medications such as antibiotics, therefore, you can enjoy the smooth and safe work environment.

Working Principle

Allpack Broad Series Mixers

You can load powder such as active ingredients and excipients into the machine tank and allow them to mix till you get the desirable mixing of the powders and ensure the treated powders are thoroughly mixed and the dose is distributed uniformly with consistency.

5.Capsule Filling Machine

The capsule filling machine has a central and is used for precisely loading different types of materials like granules, powders, liquids, and micro or mini-tablets in the capsules. It is divided into three main types:

Types of Capsule Filling Machines

Manual Capsule Filling Machine

Allpack Manual Capsule Filling Machine

As compared to its semi-automatic and automatic capsule-filling machine, this machine is dependent upon humans for its work. It is a simple and compact device, best for small-scale productions. It is usually seen in home-based pharmacies and low-volume production because of its smaller size and cost-effectivity. It is usually fitted on the desktops. There are many different models of manual capsule filling machines are available in the market. In some models, fill materials are manually loaded by the user inside the capsules while in others, these materials are filled by the machine itself.

Working Principle

Working of Manual Capsule Filling Machine

In this machine, capsule caps and bodies are manually separated. The bodies and caps are placed in separate alignment plates. A powder plate is put over the body part to fill the capsule bodies. Excess powder is scraped off by the spreader.

The powder press is positioned over the powder plate and compresses the powder inside the capsules. After removing the powder plate and powder press plate, the cap plate is situated over the body plate. Lightly pressing the arrangement, results in the locking of capsules. To remove the locked capsules from the tray, the plates are gently shaken.

Semi-automatic Capsule Filling Machine

Allpack Semi-automatic Capsule Filling Machine

It fills different types of materials using both machine and labor work. It has both automatic and manual mode of operator, making this machine a great addition in the medium scale productions. Semi-automatic capsule filling machines are easily installed in areas with space limitations because of their smaller and compact construction. Loading of powders and separation of capsule caps and bodies are done manually. This equipment executes the rest of the functions like rectification, filling, and locking.

Working Principle

Working of Semi-automatic Capsule Filling Machine

Caps and bodies are placed in the individual hoppers and transferred to their respective rectifier station. The function of the rectifier is to properly orient caps and body. After rectification, the caps and bodies are moved to the upper and lower holding rings, respectively. A lower holding ring is carried to the turntable and at this turntable, bodies are loaded with the accurate amount of powder. In the next step, the upper and lower holding rings are pressed together at the joining station to automatically lock the capsules via a pneumatic system.

Automatic Capsule Filling Machine

Allpack Automatic Capsule Filling Machine

This machine has a fully automatic mode of operation, needing no help from the human operator. No human interference results in no processing errors and saved labor wages. With its high speed, it can load hundreds to thousands of capsules per minute. It performs capsule alignment, rectification, separation, filling, rejection, and locking automatically. With a high rate of accuracy, it minimizes capsule and powder wastage. This feature makes it a cost-effective solution for the large-volume industries.

Working Principle

Working of Automatic Capsule Filling Machine- Picture Courtesy: LinkedIn

The powders and empty capsules are fed into separate powders. The capsules travel from the hopper to the rectification chamber, where they are positioned upside down. At the separation station, the caps and bodies of capsules are split from one another and are moved to the upper and lower capsule tray, respectively. At the dosing station, the capsule bodies are loaded with powders using auger fillers. Faulty capsule bodies are rejected in the rejection station. At the locking station, upper and lower capsule trays are rotated to lock the capsules. After locking, capsules are ejected from the machine via an ejection pin.

6.Capsule Metal Detector

Capsule Metal Detector

It is employed after the capsule filling machine. It makes sure that capsules are completely clean and there is no metal particle such as iron or steel over it. Capsule metal detector increases patient safety, improve their appearance, and create a smooth finish.

Working Principle

Working of capsule metal detector- Picture Courtesy: Anritsu

Capsule metal detector has spiral brushes that rotate to gently scrap off the tiny particles or other debris attached to the capsule. This machine also incorporates air flow systems to blow off the dusty particles from the surface of capsules and in case of metal particles, an unusual sound is generated by machine and alerts by light to let you know. This machine thus helps in getting rid of unwanted product.

7.Capsule Sorting Machine

Allpack Capsule Sorting Machine

It is also referred to as capsule sorter and is next in line machine after capsule deduster in the capsule filling line. Quality packaging is not done without a capsule sorting machine because defective capsules are deemed unworthy of shipment and marketing. It maintains the quality of the capsules by including only the best capsules in the final packaging. Capsule sorting machine plays a significant part in the safety and consistency of the final product. It also aids in satisfying all the regulatory obligations. It sorts and separates capsules according to size, weight, shape, color, dimension, and defect.

Working Principle

Working of Capsule Sorting Machine- Picture Courtesy: Mysoftgel

Capsule sorting machine uses different types of mechanisms like vibration, sieve, or airflow to sort the capsules.

Defective capsules will drop down from the holes of the vibratory sieve while good capsules pass through the vibratory tray and are collected in the collection bin. In the airflow capsule sorting machine, compressed air separates the defective capsules from good capsules. Exposure to compressed air will result in the moving of defective capsules away from the conveyor belt and collection in the rejection bin. Good capsules will resist air flow because of their desired weight.

It is the main machine involved in the quality control of the capsule manufacturing process. Filling and non-uniformities in the production process, result in damaged capsules. Its job is to separate and reject empty or defective capsules like lightweight, broken, or chipped capsules.

8.Capsule Counting Machine

Allpack Capsule Counting Machine

This machine is employed before the capsule bottling machine. Its main purpose is to accurately count and dispense the capsules in bottles. It significantly boosts the packaging speed by automating the counting process. It is offered with different types of sensors like optical, infrared, and mechanical sensors to precisely count and detect capsules. They are very advanced and identify even the smallest of capsules with great precision.

Working Principle

Working of Capsule Counting Machine- Picture Courtesy Cremer

It counts every type of capsule varying in size, shape, and nature. It is effective for both the hard gel and softgel capsules. Capsule counting machine reduces human error while capsule counting. Accurate count is the main function of the capsule counting machine because the pharmaceutical sector is heavily dependent on precise measurements. Moreover, it ensures the exact number of capsules per container.

First, capsules are loaded in the hopper, and they are uniformly dispensed to a vibrating tray. With the help of vibration, capsules are aligned in a single file on the vibratory tray. They are then passed to the detection module, where optical or other sensors register and count the capsules. These sensors also keep track of the counted capsules.

9.Capsule Blister Packing Machine

Allpack Capsule Blister Packing Machine

This machine is an integral part of the pharmaceutical and healthcare sectors. It offers tamper-evident packaging that discourages scammers from tampering with blister packs. Moreover, it ascertains the product integrity. There are individual compartments in the blister packs that allow dosage control. Besides these advantages, unit-dose packaging by capsule blister packing machine offers convenience to patients, due to which they can easily manage their dose.

Working Principle

Working of Capsule Blister Packing Machine- Picture Courtesy: Hoping Machinery

It efficiently packs the capsules into the blister packs. The latter consists of trays with pockets, which are made of plastics and lidding material made with aluminum. The cavities or pockets in the blister pack house capsules, while the lidding part seals these pockets or cavities. Capsule blister packing machine has a pivotal place in protecting the capsules from dust, light, moisture, and other contamination.

First, the plastic or aluminum film is heated and softened in the flathead unit. Compressed air creates a blister from this softened film. In other types of capsule blister packing machines, roller, and vacuum form a blister. Capsules are packed into the blister by the filling devices and then this filled blister is sent to the sealing area, where the cover film is sealed on the blister film.

10.Capsule Bottle Unscrambler Machine

AIPAK Capsule Bottle Unscrambler Machine

Its main job is to organize the collection of bottles. The capsule bottle unscrambling machine has a momentous role in the smooth feeding of bottles. Its job is to orient the bottles in an upright manner and efficiently transport them to subsequent machines like filling, capping, and sealing. It sorts the bottles and moves them in an aligned form. The capsule bottle unscrambler machine receives the bottles in a random sequence and makes them upright by different systems like a vibratory disc and high-frequency blower. If you desire fast and seamless capsule bottle filling, then remember to add this machine to your capsule filling machine line.

Working Principle

Working of Capsule Bottle Unscrambler Machine- Picture Courtesy: CVC Technologies

Bottles are randomly loaded in the hopper and some capsule bottle unscrambler machines use inclined conveyors to guide bottles down the hopper. They are moved to large rotary bowls with their necks leading or trailing. The hook in the capsule bottle unscrambler machine fixes them in the upright position with their neck pointing upwards. In other types of capsule bottle unscrambler machines, rotating discs, grippers, and inclined rails guide the bottles in a standing tall position.

11.Capsule Desiccant Inserting Machine

Allpack Capsule Desiccant Inserting Machine

This machine is essential in the capsule filling line because it inserts or places the desiccant packs into the capsule bottles. Desiccant packs have the important function of absorbing moisture from the surroundings, which ensures that the contents of bottles are not affected by the moisture and remain dry throughout their transportation journey and storage. Therefore, this machine has a vital role in extending the expiration period of the capsules. Moreover, it upholds the safety of the capsules by accurately placing desiccants into the bottles. The capsule desiccant inserting machine stabilizes the capsules and decreases the capsule wastage over time by reducing capsule damage by moisture and air.

Working Principle

Working of Capsule Filling Machine- Picture Courtesy: CVC Technologies

At the beginning of machine operation, the dispensing devices load a continuous desiccant strip. The capsule desiccant inserter machine has a sensor called a length verification device to confirm the length of the desiccant strip. It ensures the feed accuracy of the desiccant pack. After confirmation of length, then the packet-cutting mechanism cuts and separates desiccant packs from the strip. These desiccant bags are fed into the bottles via a filling nozzle.

12.Capsule Capping Machine

Allpack Capsule Capping Machine

This machine is installed after the capsule desiccant inserting machine. You see capped capsule bottles in pharmacies and hospitals. This capping is done by a capsule capping machine. It is integral in sealing the top of bottles with matching caps. This machine is pivotal in accomplishing secure packaging and preserving product integrity. It accurately caps a large volume of bottles, which makes it important in both small and large productions. It is effective in securing the closure of capsule bottles. With the capping of bottles, it averts the risk of leakage and spillage. This machine also forms airtight and tamper-evident seals, that make it impossible for defrauders to access the inside of capsule bottle packaging.

Working Principle

Working Principle of Capsule Capping Machine

The working of this machine starts by pouring caps in the cap hopper. These caps are transferred to the cap-dropping part that puts the caps on the top of capsule bottles. These capped bottles are moved to a cap screwing station, where a gripper keeps bottles firmly in place and spindle wheels or spinning disks exert torque on the caps to secure them on bottles, spinning the caps to acquire firm sealing.

13.Capsule Induction Sealing Machine

Allpack Capsule Induction Sealing Machine

This machine has a significant place when it comes to sealing capsule bottles. It creates a strong seal around the rim of the bottle to protect the inner capsule contents. With the help of electromagnetic current, it bonds the film layer to the bottles, consequently creating a strong hermetic seal. This machine does not come in direct contact with the bottles, thus preventing the contamination of the bottle content. Its main function is to ensure the freshness and potency of the capsules. Moreover, it also has a role in leakage and tampering prevention.

Working Principle

Working Principle of Capsule Induction Sealing Machine- Picture Courtesy: iPharmachine

The capped bottles are transferred onto the conveyor of the machine. These bottles pass through a rejection center where poor quality and defective bottles are discharged from the machine. In the next step, compliant capsule bottles travel to the sealing head. At this station, high-frequency electric current is produced. This current is passed to the foil layer that rapidly heats up. At high temperatures, the foil melts and attaches to the mouth of bottles. Then bottles leave sealing heads and are cooled off, which results in solidification and bonding of foil to the top of bottles, forming a long-lasting seal.

14.Capsule Labeling Machine

Allpack Capsule Labeling Machine

This machine is integrated at the final stages of the capsule filling line. Capsule bottles with different information labels are seen in the market. These labels are put on the exterior of bottles by the capsule labeling machine. It sticks straight and wrinkle-free labels every time on the capsule bottles, playing an important role in improving the aesthetic appeal of the capsule bottles. Capsule labeling machine has an essential role in product communication and branding. It informs users about ingredients, nutritional content, expiry dates, and bar codes. Some types of capsule labeling machines, also place tracking labels on the capsule bottles.

Working Principle

Working Principle of Capsule Labeling Machine- Picture Courtesy: BBK - Labelling Automation & Serialisation

The working process begins by placing bottles on the conveyor, which allows for controlled movement of bottles. Label roll is placed on the film holder, from where it is spooled off by the drive wheel. When bottles reach the labeling head, labeling roller and label press apply and press labels against the moving bottles. The sensor is also incorporated in the capsule labeling machine, which ensures correct label placement by sensing the mark on the labels.

15.Capsule Cartoning Machine

Allpack Capsule Cartoning Machine

It is the last in-line machine in the capsule filling line. A capsule cartoning machine is also called a capsule cartoner. It is an important machine because it has a central place in the secondary packaging of capsule content. Its principal task is to form boxes for storing capsule bottles. This machine is effective in erecting, folding, filling, gluing, and, sealing the cartons. It comes with a handy set of advantages, providing the capsule products additional protection against mechanical damage and stress during transportation. It also automates and streamlines the final steps of capsule packaging with its remarkable efficiency and seamless consistency.

Working Principle

Working Principle of Capsule Cartoning Machine- Picture Courtesy: Körber Pharma

Its running operation commences with the feeding of blank cartons in the carton magazine. The Carton erecting station erects and folds the blank cartons to obtain a three-dimensional box-like structure. Capsule bottles are deposited in the box from the top open end of the carton. There are different mechanisms like gravity drop and pick and place systems for placing the bottles inside the erected carton. Next at the carton closing station, glue or other adhesives close and seal the filled cartons.

Conclusion

A capsule filling line is needed in modern times because it is the absolute best system for processing capsules from raw materials till the final stages of packaging. Article on the ‘15 Machines in The Capsule Filling Line: From Raw to Final’ provide immense details involved in capsule manufacturing and packing. They automatically process the raw ingredients and shapes into capsules without human involvement. These ancillary machines have a pivotal part in the smooth capsule manufacturing process. They help to achieve high regulatory standards because of their sterile and hygienic processing, So, if you want to purchase different machines in capsule filling machines then, Allpack is the best place. Here, we offer numerous kinds of capsule filling machines at favorable prices.

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Capsule Bottle Size Chart

Capsule Filling Machine

Capsule Bottle Size Chart

In today’s pursuit of quality living, bottles are no longer just simple containers. Their size and shape carry countless design ingenuity and practical considerations. Many things require bottles for packaging, such as water, wine, medicine, grains, etc.

In the pharmaceutical industry, the capsule bottle size is not just about simple container selection, it is related to the safety, ease of use, and patient experience of drugs. From precise capacity control to user-friendly opening design, every detail has been carefully considered.

The capsule bottle size should not only meet the characteristics and storage requirements of the drug, but also be easy for patients to accurately access and carry. Next, we will delve into the information about capsule bottle sizes together.

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1.What Is Capsule Bottle Size Chart?

Capsule Bottle - Sourced: alaninu

Capsule bottles have gained significant popularity in the pharmaceutical and health product sectors for their versatility in storing and packaging a wide range of products. These bottles are suitable for containing both liquid and solid health capsule items, such as vitamins.

The design of these bottles often incorporates a rotating cap, simplifying the process of opening and closing for users. Moreover, the capsule bottles’ moderate size allows for convenient filling and retrieval of medications, making them a practical choice for packaging purposes.

The size specifications of capsule bottles are one of the key factors to ensure the safe and effective storage of drugs and health products. Its size specifications vary depending on different products, covering multiple aspects such as diameter, height and circumference. The detailed capsule bottle chart is as follows:

Push-N-Turn Child Resistant Bottle:

Push-N-Turn Child Resistant Bottle - Sourced: pharmapump

Bottle Size	8 dram	11 dram	13 dram	16 dram	20 dram	30 dram	40 dram	60 dram
Height	2.1875	2.3125	2.3125	2.875	2.3125	3.375	3.50	5.125
Insider Diameter	0.875	1.00	1.25	1.25	1.625	1.625	1.8125	1.8125
Circumference	2.745	3.140	3.925	5.1025	5.1025	5.495	5.495	5.495

Reversible Bottle

Reversible Bottle - Sourced: theplasticlab

Bottle Size	8 dram	11 dram	13 dram	16 dram	20 dram	30 dram	40 dram	60 dram
Height	2.3125	2.3125	2.875	2.875	2.3125	3.375	3.50	5.125
Insider Diameter	1.00	1.25	1.25	1.625	1.625	1.625	1.8125	1.8125
Circumference	3.140	3.925	3.925	5.1025	5.1025	5.495	5.495	5.495

Preferred child resistant bottle

Preferred Child Resistant Bottle: Sourced: sks-bottle

Bottle Size	8 dram	11 dram	13 dram	16 dram	20 dram	30 dram	40 dram	60 dram
Height	2.25	2.25	2.375	3.00	2.625	3.125	3.25	3.50
Insider Diameter	0.75	0.875	1.00	1.00	1.25	1.25	1.25	1.25
Circumference	3.140	3.725	4.125	4.125	5.295	5.495	6.475	6.675

Snap cap bottle

Snap Cap Bottle - Sourced: premiumvials

Bottle Size	8 dram	11 dram	13 dram	16 dram	20 dram	30 dram	40 dram	60 dram
Height	2.125	2.3125	2.3125	2.875	2.125	2.4375	3.375	5.125
Insider Diameter	0.875	1.00	1.25	1.25	1.75	1.75	1.75	1.75
Circumference	2.745	3.140	3.925	3.925	5.495	5.495	5.495	5.495

2.What Are the Benefits of Capsule Bottles?

Capsule bottles, as a common packaging solution, offer numerous benefits. Here is a thorough description of key benefits associated with capsule bottles:

Clean and non-pollution

Non-pollution - Sourced: flaticon

The high cleanliness standards and pollution-free characteristics ensure the high quality level of the container, avoiding the accumulation of dust on the surface of the bottle and the touch of hands, bottle preforms, and containers, greatly reducing bacterial contamination and corrosion.

High quality and high standards

GMP Standard - Sourced: miaspharma

The manufacturing of capsule bottles conforms to the national standards and GMP requirements for packaging materials, ensuring their high quality and standards.

The consistency and accuracy of thickness and quality are effectively guaranteed, while high permeability and high sealing are also ensured.

Security and protection

Security - Sourced: pdq

For some medicines that require shading and preservation, capsule bottles also provide effective solutions, such as using brown bottle bodies or adding sunscreen.

Wide application

Wide Application - Sourced: medshadow

Capsule bottles are extensively utilized across the health product and pharmaceutical industries for safeguarding and containing various capsule-shaped nutritional supplements, which includes vitamins, minerals, herbal extracts, and more.

3.What Are the Common Colors of Capsule Bottles?

With regard to color, the selection for capsule bottles is not limited to a single one. To cater to the varying demands of products, brands, and consumers, manufacturers typically offer a diverse array of colored capsule bottles. These colors may include white, transparent, blue, green, brown, and more, each chosen with specific purpose and considerations.

Transparent capsule bottle

Transparent Capsule Bottle - Sourced: Adobe Stock

Transparent capsule bottles are frequently chosen to showcase the contents of the product, enabling consumers to visually appreciate the color and texture, thereby enhancing its overall attractiveness.

White capsule bottle

White Capsule Bottle - Sourced: pexels

White, a light hue with excellent reflectivity, is less prone to absorbing sunlight compared to darker bottles. This attribute aids in maintaining the stability of medications, preventing them from degrading due to light exposure.

White capsule bottles can be made from various materials, including plastics (e.g., PET, HDPE) and glass, which typically possess robust drug resistance. These materials effectively safeguard medications from external factors, thereby extending their shelf life.

Brown capsule bottle

Brown Capsule Bottle - Sourced: dreamstime

Brown or other dark colored capsule bottles are commonly used for drugs or health products that need to be avoided from light, because the dark bottle body can effectively block light and prevent it from causing adverse effects on the product.

In addition, different colors may also signify different brands or product lines, helping consumers quickly identify and choose the products they need.

In summary, capsule bottles do have multiple colors to choose from, which not only meet the packaging needs of the product, but also increase its attractiveness and recognition.

4.What Are the Different Capsule Sizes?

Because drugs vary in their required doses, it is necessary to have different capsule sizes to accommodate varying amounts of medication. Low dose drugs may be suitable for smaller capsules, while high-dose drugs require larger capsules.

In addition, the different capsule sizes also take into account the convenience of production and use. Smaller capsules may be easier for patients to swallow, while larger capsules can accommodate more medication and reduce medication frequency.

Different Capsule Sizes - Sourced: pharmacy180

According to the figure above, the capsule sizes are categorized into 000,00, 0, 1, 2, 3, 4, and 5, with the size 00 being the most frequently used. The specific weight, capacity and external diameter of capsule are detailed as follows.

Size	000	00	0	1	2	3	4	5
Weight (mg)	163	118	95	75	60	47	38	28
Capacity (ml)	1.37	0.91	0.68	0.50	0.37	0.30	0.21	0.13
External diameter (mm)	9.91	8.53	7.64	6.91	6.35	5.82	5.31	4.91
Length (mm)	26.14	23.30	21.70	19.40	18.00	15.90	14.30	11.10

Capsules of different sizes take into account various factors. Reasonable size design can improve production efficiency, reduce production costs, and facilitate storage and transportation.

At the same time, the size of the capsule is also related to the adaptability of the capsule machine. The appropriate size can ensure the smooth operation of the capsule in the capsule machine and reduce the failure rate.

5.How Many Capsules Can Be Packaged in Different Bottle Sizes?

How do you know how many capsules different sizes of capsule bottles can hold? If you want to know how many capsules can be filled in different bottle sizes, you need to consider the following factors:

The volume of capsule bottle

The Volume of Capsule Bottle - Sourced: guysloveov

First of all, you need to know the internal volume of the bottle. This can usually be estimated by measuring the height, diameter, or bottom area of the bottle. If you have an accurate measuring tool (such as a measuring cup or cylinder), you can directly measure the capacity of the bottle (in milliliters or cubic centimeters).

Capsule volume

Capsule Volume - Sourced: pharmacy180

Next, you need to know the volume of each capsule. This can usually be estimated by measuring the size of a capsule (such as length, width, and height) and using a volume formula. If you have the specifications of the capsules on hand, you can use these data directly.

The arrangement of capsules in the bottle also affects how many capsules can be filled. If the capsules can be tightly arranged, then the bottle can hold more. However, if there are gaps between capsules or a specific arrangement is required (such as stacking or interlocking), the quantity may decrease.

In a word, the number of capsules that a bottle can hold is determined by the size of the capsules and the size of the bottle, as shown in the following table:

Capsule Size Bottle size	000	00	0	1	2	3	4	5
30ml	21	32	44	60	81	100	142	231
60ml	43	65	88	120	162	200	285	462
90ml	65	98	132	180	243	300	428	692
120ml	87	131	176	240	324	400	571	923
150ml	109	164	220	300	405	500	714	1154
180ml	131	197	264	360	486	600	857	1385

6.What Factors Should You Consider When Choosing Capsule Bottle Size?

Choosing right capsule bottle size is a meticulous and important process, so you should consider multiple factors to ensure that the selected product meets actual needs. The following are some key considerations aimed at helping you make wise purchasing decisions.

Capsule size

Capsule Size - Sourced: yuyamarx

The first thing that you should pay attention is the size of the capsule. Capsules from different brands may have slight size differences, so it is crucial to ensure that the capsule bottle you choose can accommodate these capsules. The inner diameter of the bottle should be slightly larger than the maximum diameter of the capsule to ensure smooth insertion and removal of the capsule.

The number of capsule

The Number of Capsule - Sourced: pharmafranchisecompanies

In addition to capsule size, you also need to consider the number of capsules that need to be stored. If the expected storage capacity is large, it would be more appropriate to choose a bottle with a larger capacity. At the same time, considering the possible gaps between the capsules, choosing a slightly larger bottle can also ensure that the capsules are not too crowded inside the bottle.

Features of capsules

The Feature of Capsule - Sourced: asiangelatin

If the drug in the capsule is sensitive to light, it is very important to choose a capsule bottle with shading properties. Generally speaking, brown PET bottles provide better barrier performance, which can more effectively block light and protect drugs from being degraded by light.

The demand of consumers

The Demand of Consumers - Sourced: Foodnavigator

The capsule bottle size should be convenient for people to hold and use. Especially for the elderly or those with weaker hand strength, bottles that are easy to grip and operate should be chosen. The opening design of the bottle should also consider the convenience of use, such as whether the bottle cap is easy to open and close, and whether it has leak proof function.

Besides, the capsule bottle size should be convenient for storage and transportation. For example, for medications that need to be carried out, lightweight and easy to carry bottles can be chosen. For drugs that require long-term storage, a well sealed bottle can be chosen to prevent moisture and spoilage.

Conclusion

After reading this article, you must have gained significant insight into the capsule bottle size. When choosing the capsule bottle size, you need to consider many factors in order to choose the appropriate size. If you wan to know further information, you can consult Allpack at your convenience.

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Pill Filling Machine: The Complete Buying Guide in 2024

Capsule Filling Machine

Pill Filling Machine: The Complete Buying Guide in 2024

Do you know Pill is the world most used solid dosage form needs specialized filling machine? A pill filling machine is an affordable and convenient machine carrying promising responsibilities of filling sensitive and general medications till you.

Stay on this page to know more about ‘pill filling machine’, we are here to help and described expert suggestions related to this machine. by the end of this blog, you will be able to know to select machine of your choice that can boost your filling production line. So Ready Steady Go!

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1.What Is Pill?

Pill

Various Pill Formulation

A pill also called a tablet or capsule is a medicine that is administered as an oral dose. A pill is a small, solid dose of medication that you take by swallowing. It’s a simple interface to get medicine in the body. It consists of a mixture of the active substances and the excipients it contains. The active substances are usually in the form of a powder. The powder is then pressed or compressed into a solid dosage.

2.What Is Pill Filling Machine?

Allpack Pill Filling Machine

A pill filling machine is a type of equipment, to automate the process of filling pill or capsules for medication. The materials they fill with active pharmaceuticals ingredients include powder, pellets, tablets, granules, liquids, or various combinations. These machines can process a lot of pills; less manual labor is required which boosts productivity.

3.What Are Benefits Of Pill Filling Machine?

There are several benefits provided by pill filling machine to the pharmaceutical industry. Let’s discuss each benefit in more detail.

Increased production efficiency

Efficient Production

The process of pill filling or capsule is automated by the pill filling machine, which contributes to increased production speed. Compared to manual filling, these machines can fill a large number of pills in a shorter amount of time.

Accurate dosages

Dosage

Medication is dispensed precisely into each pill or capsule by filling machines. This lowers the possibility of under- or overdosing by ensuring that the dosage is accurate and consistent. Exact dosages are essential to the efficiency and security of pharmaceuticals.

Reduced risk of human error

Risk of Human Errors- Picture Courtesy: tablet & capsule

Human error in manual pill filling can lead to inconsistent filling and incorrect dosage. By automating the procedure, pill filling machine assist removing these mistakes. These lower the possibility of errors and guarantee the consistency and quality of the filled pill.

Time and labor savings

Time and Labor- Picture Courtesy: USA Today

Pharmaceutical companies can reduce labor expenses and save time by automating the pill filling process. The amount of pill that pill filling machines can handle decrease the need for manual labor. This increase worker productivity by enabling them to concentrate on other crucial responsibility.

Flexibility in Filling

Allpack Pill Filling Machine for Manufacturing

It is possible to program pill filling machine to fill various kinds and sizes of pills and capsules. This offers flexibility, enabling pharmaceutical companies to use a single machine to produce multiple medications. It streamlines the manufacturing procedure and eliminates the requirement for several machines to handle various pill sizes.

4.What Are Industrial Applications Of Pill Filling Machine?

Pill filling machines have many industrial uses, they aid in the precise and effective automation of the tablet, capsule, and pill filling process. Some of these applications are:

Pharmaceutical Industry

Pills or Capsules in Pharmaceutical Industry- Picture Courtesy: Science Friday

Pill filling machines are widely used in the pharmaceutical industry to fill tablets, capsules, and pellets on daily basis. A pill filling machine accelerates the large-scale filling process, guaranteeing a high degree of accuracy, correctness, and precision in the product volume dispensed.

The superior automation, high consistency, robustness, and dependability of pill filling machines ultimately help to achieve specific production goals and meet the demands of pharmaceuticals industry.

Nutraceutical Industry

Pills or Tablets in Neutraceutical Industry

Pill filling machines are used in nutraceutical industry to fill capsules or tablets with different kind of dietary supplements, vitamins, and herbal products. The pill filling machine guarantees accurate dosage and constant quality which improves production efficiency.

Agriculture Industry

Agriculture Industry

The producers of growth promoting bio-stimulants for the agriculture sector are continuously making progress, whether it is through the production of tablets, capsules, or small pellets. These products are preferred by many agricultural businesses because they facilitate cell division, growth promotion, and the rapid development of crops.

Chemical Industry

Pills in Chemical Industry- Picture Courtesy: Valley news live

Pill filling machine have the widest range of uses in chemical industry. There are many hazardous conditions as you manufacture, fill, and package chemical goods. When it comes to observing and filling chemical products, pill filling machines are vital and protective.

Veterinary Industry

Pill or Tablets in Veterinary Industry- Picture Courtesy: Crossroadsanimalhospital

The veterinary industry frequently uses pill filling machine to dispense oral medication at high-level which are used to treat the conditions in animals.

Cosmetic Industry

Pharmaceuticals & Cosmetics- Picture Courtesy: Antonpaar

Pill containing powder, oil, and other cosmetic formulation can be filled with the help of pill filling machine. This insures concise of the cosmetic products and helps to expedite the manufacturing process.

Food Industry

Egg Colors in Capsules- Picture Courtesy: Eatingrules

The pill filling machine promises an intelligent and timely reaction wether it has to do with filling capsules or big or small tablets. A pill filling machine is the ideal tool for filling pulses, almonds, coffee beans, chocolate beans, and other food items.

5.What Are Types Of Pill Filling Machine?

The industries require different kinds of pill fillers, so different kind of pill filler machines are available in the market. Three major categories can be used classify pill filler.

Manual Pill Filling Machine

Manual Pill Filling Machine- Picture Courtesy: Anchormark

A manual pill filling machine is a kind that needs to be operated by hand in order to fill tablets or capsules. It is made up of a tray or platform on which the tablets and capsules are left empty. The user then uses handheld tool or machine to manually fill the capsules or tablets with the required amount of ingredients.

A pill filling machine can be useful for small-scale production or for people who prefer a hand-on approach; even though it might take longer time then automated machines.

Semi-Automated Pill Filling Machine

Allpack Semi-Automated Pill Filling Machine

A Semi-automated or hybrid pill filling machine combines both manual and automatic components. The semi-automated pill filling machine requires fewer efforts from the operator. Its design allows it to automatically fill and rearrange the capsule cap in accordance with preprogramed computer code, so long as the apparatus complies with the industry’s stringent hygienic standards.

It can be configured for manual operations to generate a restricted number of capsules. The semi-automated pill filling machine is sturdy build and practical design make it extremely long lasting and low-maintenance piece of machinery for pharmaceutical industry.

Automated Pill Filling Machine

Allpack Automatic Pill Filling Machine

Automatic pill filling machine is made and designed to fill the required pharmaceutical ingredients into the capsules either automatically or directly without the need of operator or external command. These machines follow commands entered into them and are programmed by the computer.

The pharmaceutical industry uses this automatic pill filling machines primarily for large-scale capsule production. Pill filler are capable of efficiently packing fine or powder into the capsule body.

6.What are the parts of pill filling machine?

Allpack Parts of Pill Filling Machine

In a pill filling machine, there are several key parts that work together to facilitate the filling process. Some of the main parts include:

Hopper

This is the container that holds the content of the pill and filling content. It contains the majority of the ingredients that are going to be put into the pill.

PLC Touschreen

PLC is a computer program that allows the operator to control the machine by touching the touch screen interface. Operators enter commands, change settings, and track the machine’s performance by touching the screen.

Warning Light/ Alarm

This sensor or part in the pill filling machine uses light to detect the presence of pills. This ensures that the pills are accurately counted and placed in the proper container. The photoelectric eye is an important part of the pill filling machine. It assists in the detection and regulation of the filling procedure.

Feeder

Pills are offered to the machine by the help of feeder. This unit helps in the opening of the pills in rotary die.

Pill Filler

An optimized amount of drugs is filled in pill filler. Once it is filled it is now set to closing again.

Electric Cabinet

Electrical components are constructed in an enclosed box for user’s safety. It includes wires, plugs, etc to run process.

7.Is pill filling machine can cause cross-contamination?

Cross-Contamination in Pills- Picture Courtesy: Crotraining

No, the machine body is made up of stainless steel and carefully constructed to control chances of cross-contamination but if appropriate maintenance and cleaning procedure are not followed it may leads to cross- contamination. To avoid contamination or ingredient mixing, it’s crucial to make sure the machine is completely cleaned in between the batches or types of pills. The risk of cross contamination in pill filling machine must be reduced by routine cleaning and adherence to good manufacturing practice.

8.What Product can be filled by Pill Filling Machine?

Product Filling in Capsules- Picture Courtesy: Pharmaapproach

The main purpose of pill filling machine is to fill different kind of pills or capsules. A large variety of pharmaceutical products can be processed by these machines, which includes:

Solid Oral Medications:This includes tablets, caplets, capsules, and soft gelatin capsules.

Granules:Certain medications are formulated as granules, and pill filling machines can fill them into capsules or sachets.

Pellets:These are small, spherical medication forms. Pill filling machines can accurately fill pellets into capsules or other appropriate containers.

9.What are Problems and Solution of Pill Filling Machine?

When it comes to pill filling machines, there can be various problems that may arise during operation.

Some common issues include:

Filling error- picture Courtesy: Berxi

Inconsistent Filling: This occurs when the machine does not dispense the correct amount of medication into each pill or capsule. It can be caused by factors like improper calibration or worn-out parts.

Solution: Provide operators with thorough training on how to use and maintain the pill filling machine correctly. This helps prevent errors and ensures smooth operation and avoid inconsisties.

Capsule Jamming

Jamming: Jamming happens when pills or capsules get stuck in the machine, leading to a halt in the filling process. This can occur due to issues with the feeding mechanism or incorrect alignment.

Solution: Slow the filling speed. Calibrate the machine. check type and shapes of pills being subjected to the machine.

Contamination problem- Picture Courtesy: Safecor

Contamination: Contamination can occur if the machine and its components are not properly cleaned and sanitized. It can lead to compromised product quality and safety.

Solution: Follow proper cleaning and sanitization protocols to prevent contamination. Use approved cleaning agents and regularly clean all contact surfaces.

10.What are the Top Manufacturers Companies of Pill Filling Machine?

Manufacturers- Picture Courtesy: Sgs

There are several top manufacturers of pill filling machines known for their quality and reliability. Some prominent companies in this industry include:

Bosch Packaging Technology
IMA Group
MG America
Romaco Group
Allpack
Marchesini Group
Uhlmann Group
Körber Medipak Systems
CAM Packaging Machines
ACG Worldwide

These companies offer a range of pill filling machines with various features and capabilities to meet different production needs. It's always recommended to research and compare different manufacturers to find the one that best suits your requirements.

11.What Factor Should be Considered when Purchasing Pill Filling Machine?

When purchasing a pill filling machine, there are several factors to consider:

Pill Fill Production Requirements

Production Capacity:Determine the desired production output and choose a machine that can meet your volume requirements.

Look for a machine that can consistently fill pills with the correct dosage to ensure product quality and safety.

High Flexible Output- Picture Courtesy: Depositphoto

Flexibility:Consider the machine's ability to handle different types and sizes of pills, as well as the ease of adjusting settings for different production needs.

Opt for a machine that is user-friendly and has intuitive controls, reducing the learning curve for operators.

Pill filling machine compliance with international standards- Picture Courtesy:Fierce Biotech

Compliance with Regulations:Ensure that the machine complies with relevant regulatory standards and guidelines for pharmaceutical manufacturing.

Allpack cost effective pill filling machine

Cost:Consider the initial investment cost, as well as any additional costs for installation, training, maintenance, and ongoing operational expenses.

Research the manufacturer's reputation and read reviews from other customers to gauge their experience with the machine.

Conclusion

When it comes to purchasing a pill filling machine, it's important to carefully consider factors such as production capacity, accuracy, flexibility, ease of use, maintenance and support, compliance with regulations, cost, and the manufacturer's reputation. By taking these steps in mind, you can make a well-informed decision and find a pill filling machine that meets your specific needs. For any queries or purchase please feel free to contact Allpack team right now.

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Automatic Capsule Machine: The Complete Buying Guide In 2024

Capsule Filling Machine

Automatic Capsule Machine: The Complete Buying Guide In 2024

Are you interested in buying an automatic capsule machine and getting its related information? Does your facility involve capsule making process? Is an automatic capsule machining a part of your production line? Do you want proper guidance regarding the working principle and types of automatic capsule machines available globally? So, you are at the right place that will help resolving all your queries related to automatic capsule machine and will support you in selecting the best type. Please read the complete buying guide to get much possible knowledge from it.

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1.What Is An Automatic Capsule Machine?

Allpack Automatic Capsule Machine

An automatic capsule machine is a highly specialized type of machine that is used to fill and encapsulate different types of particles, powders into capsules in an efficient manner. These machines fill various types of substances in capsules and then are consumed for various reasons. Complete processes in an automatic capsule machine are carried out in an aligned sequence that makes the production precise and uniform.

2.What Are The Industrial Applications Of An Automatic Capsule Machine?

Automatic capsule machines are currently present in all types of small and large scale industries. These industries have optimal usage of automatic capsule machine to enhance their productivity. Some of the industries using automatic capsule machines are

Pharmaceutical Industry

Pharma Capsules - Picture Courtesy: Pharma Franchise Company

Pharmaceutical industry is the largest consumer of an automatic capsule machine as capsules are one of the orally consumed medications globally. These capsules of different sizes and shapes are filled and sealed using automatic capsule machines in an efficient manner. Machines ensure that the ratio of dosage inserted is according to the standards and is approved by different clinical trials.

Food Industry

Nutrient Supplements

Food industry is also a consumer of an automatic capsule machine as it also produces products that are in the form of capsule. Ingredients like chocolates, jellies, vitamins and supplements are filled in these capsules that make consumption easier and also attract adults towards them.

Cosmetics Industry

Cosmetics Hyaluronic Acid Capsules - Picture Courtesy: Republic Cosmetics

Some of the vitamins and protein health care products that are used as cosmetic products are also present in the form of capsule. These capsules are filled and sealed using an automatic capsule machine. It makes the product look presentable and attracts number of customers towards it.

Agricultural Industry

Nutrient Capsules For Agriculture

Capsules having organic fertilizers and nutrients that are useful for agricultural land are also manufactured using an automatic capsule machine. These capsules generally contain products that are essential for agricultural land and to improve its internal strength.

3.What Are The Advantages Of An Automatic Capsule Machine?

Some of the advantages of an automatic capsule machine are

Productivity

Capsules Productivity

The designing of an automatic capsule machine is done in a way that it helps the manufacturer to produce large volume of capsule in limited time. The procedure is done to keep the system remain efficient in each of the capsule and to keep complete similarity in them.

Efficiency

Efficient Manufacturing Of Capsules

Efficiency is another benefit that can be gained using an automatic capsule machine. It is taken in the context of chemical composition that each of the capsules has equal dosage formulation to work effectively. The mechanism ensures consistent flow to keep the medication dosage filled in an efficient manner using an automatic capsule machine.

Formulation Flexibility

Flexible Formulation Of Capsules

One of the leading advantages of an automatic capsule machine is that it allows wide range of capsule filling in a single machine. Whether it is powder, pellets or granules that has to be filled in capsules, a single automatic capsule machine can accommodate each of the formulation in it in an efficient and precise manner.

Consistency

Elongated Consistent Capsules Making

Quality is a factor that helps to check the consistency of an automatic capsule machine. It provides flexibility in producing capsule by using highly accurate sensors and actuators. These components help to fill accurate amount of formulation in capsules and maintain consistency in them.

4.What Is The Steps Involved In Working Of An Automatic Capsule Machine?

Automatic Capsule Filling - Picture Courtesy: grupobsg

The working of an automatic capsule machine follows several series of steps. These are internally coordinated with each other to maintain the system run efficiently .These steps are

In the first step, both the empty capsules and powder in inserted into their respective hoppers present at the top of machine. Both the object s is delivered in an automatic sequence to the filling stations where they are blocked by highly advanced mechanism.

In the block-shelf, the capsule direction is using guide slots that adjust the capsules both upward and downward for proper filling. Both of portions of capsules are separately adjusted into the lower and upper molds and stick by vacuum suck so that chances of falling can be eliminated.

In the third step the filling of capsules placed in die mold is carried out. The material released from the powder hopper enters into these capsules cap by filling nozzles in an accurate amount.

After the completion of filling process, both the cases of capsules are locked together by a dose plate so that no spillage can occur.

As the capsules are ready, they are discharged from the system through a proper ejection system that continuously pushes them out from the mold surface. The mold gets cleaned after each capsule formation by a vacuum chamber to maintain consistency in the system.

5.What Are The Main Components Of An Automatic Capsule Machine?

Components In An Automatic Capsule Machine

The main components of an automatic capsule machine are

Hoppers

Both of the powder and capsule hoppers are present in an automatic capsule machine that is used for holder of filling material and capsules respectively. A capsule hopper is mostly with a vibration support that ensures segregation of capsules and to allow their free flow.

Operation Panel

An operation panel of an automatic capsule machine contains all the options involved in product processing. The productivity is controlled by increasing and decreasing of speed controller present on this operation panel. Other options like start on and off button, emergency buttons and others are also present in this panel.

Vibration Device

As capsules are attached altogether in a hopper it is always necessary to segregate them and separate each of them to maintain efficiency and consistency in system.It minimizes the risk of error and keeps capsule flowing individually to fill and get sealed.

Vacuum Chamber

Vacuum chamber in an automatic capsule machine has dual functions to perform. Initially it helps in capsule segregation and then also supports in cleaning the machines to maintain hygienic environment. These are mostly present at the bottom side of an automatic capsule machine where it can perform both of the tasks efficiently.

Filling Nozzle

The capsule material is dispensed into the capsules through a highly systematic filling nozzle that helps in its release and also in an accurate manner. The specific limit of material is dispensed so that consistency is maintained in each of the capsule.

Ejection System

Once the capsules are filled and sealed properly, they are taken out of the system through this ejection system. An ejection system works an offloading channel from where all the capsules are collected and moved forward for their packaging and transportation.

6.How Does An Automatic Capsule Machine Improve The Efficiency Of A Process As Compared To Other Types Of Capsule Machines?

Automatic Capsule Filling Machine

An automatic capsule machine has an ability to perform at a high speed and makes rapid production in a very short interval of time. It processes thousands of capsules filling and sealing procedures in a single day with its highly automatic system and maintains the quality in each single capsule.

Further improving the efficiency of any system is also due to its compatibility with different sizes of capsules. Each capsule is filled with an accurate amount of dosage as defined standard and filling duration allowed to it. The machine remains user friendly and gives an access to reach out all its working parameters that can help in improving the systems efficiency.

7.How Different Sizes Of Capsules Are Produced In A Single Automatic Capsule Machine?

Capsule SizeChart- Picture Courtesy: LFA Capsule Fillers

Flexibility with different sizes of capsules and their filling is one of the most important benefits an automatic capsule machine can offer. It can easily accommodate various sizes of capsules in it as it holds an adjustable filling station and nozzle that varies according to the size of capsule. These can easily be changed and modified according to their sizes in just a fraction of time.

The parts of an automatic capsule machine are interchangeable that can be replaced easily by the operator. This makes efficient filling and sealing of different types of capsules in a single machine to make the system economical.

8.What Are The Major Differences Between A Manual Capsule Machine And An Automatic Capsule Machine?

Some of the differences between a manual capsule machine and an automatic capsule machine are

Productivity

Improved Productivity

A manual capsule machine is mostly used in small scale or cottage industry where the productivity is in low volume. It has a capacity of producing few hundreds of capsules in a hundred or depends upon the working efficiency of the operator.

Mostly high and medium scale industries use automatic capsule machines to make their run in a faster way. Thousands of capsules of different sizes and shapes can easily be produced in a single automatic capsule machine.

Structure

A manual capsule machine has a simple structure and handed completely by manual operations. A hopper is present in it with manual placing of capsules.

Whereas in an automatic capsule machine has a highly systematic processes for filling, sealing and feeding of capsules. It has a complex structure and sometimes include conveying system too that helps in movement of capsules within the system.

Application

Both of the machines are applied in pharmaceutical, food, cosmetics, agricultural and chemical industries depending upon their requirements and productivity.

Precision And Accuracy

Capsule Filling Machine Tool

Manual capsule machines are low in precision and accuracy due to manual involvement and slow process.The machines precision and accuracy solely depends on the performance of operator.

On the other hand an automatic capsule machine has a high precision and accuracy levels to maintain consistency in the system. Each of the capsule formed show similarity in structure and composition both.

9.What Are The Process Line MachinesAssociated With An Automatic Capsule Machine?

Auxiliary machine are associate with an automatic capsule machines to enhance its productivity and to produce highly quality products that can attract more and more customers towards it. Some of them are

Capsule Counting Machine

Capsule Counting Machine

To accurately count the number of capsules present in a batch, capsule counting machine is one of the advanced modes to do so. The process of a capsule counting machine saves a lot of time and does it with greater efficiency as compare to manual counting.

Blister Packaging Machine

Blister Packing Machine

For packaging of completely processed capsules, blister packaging machines are used in many of the industries that make their packaging easier. Blister packaging machines work in a highly efficient manner and packages capsule according to the shape of packaging and the number defined to them.

Conclusion

For high productivity of capsules in an efficient and precise manner, an automatic capsule machine is the most reliable thing to select. It can be used for filling and sealing of capsules that are different in size and shape. But you need complete machine related information to select the right type of automatic capsule machine for your setup. For this All pack is always here to provide you complete machine related information and help you in buying the best product. For any query contact our customer representatives that are available 24/7 for your guidance.

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Vitamin Capsule Filler: The Complete Buying Guide in 2024

Capsule Filling Machine

Vitamin Capsule Filler: The Complete Buying Guide in 2024

Do you know that buyers and sellers prefer capsules more than tablets? It is because capsule filling is an ideal way to fill active ingredients because of its quick dissolution, taste disguising, and prolonged shelf-life. With capsule filler, vitamin capsule filler comes to mind.

Vitamin capsule filler is known for its extreme efficiency, high accuracy, and, clean operation. This machine is leading the medicinal market and brings exceptional quality results to the brands. It has a prominent place in not only the healthcare sector but also holds a special place in the cosmetic industry.

This informative guide will impart useful knowledge about various mechanical parts, operations, and computerized technology in the vitamin capsule filler.

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1.How Can You Define Vitamin Capsule Filler?

Allpack Vitamin Capsule Filler

A vitamin capsule filler is a machine that admits the pharmaceutically active ingredients and vitamin powders inside the empty capsules using filling rings. It is also termed as vitamin encapsulator and vitamin capsule-filling machine.

It performs processes such as alignment, rectification, separation, packing, and, counting of vitamin capsules. It is the main part of the pharmaceutical and nutraceutical industry and has a vital role in feeding powders, granules, pellets, oils, pastes, and gels inside the two-piece vitamin capsules. It has the benefits of precise vitamin dosing, capsule sorting, and visual inspection of empty capsules.

2.How Does Vitamin Capsule Filler Benefits Businesses?

High demand for vitamin supplements propels the expansion of the vitamin capsule filler market. This machine increases production efficiency and fills accuracy. Here is the list of benefits that vitamin capsule filler offers businesses:

Fulfills Stringent Demands

Fulfills Stringent Demands by Vitamin Capsule Filler- Picture Courtesy: Kesri Clinic

FDA and other drug regulatory authorities have strict manufacturing guidelines for filling drugs and other supplements and vitamin filling in capsules is no exception to the rule. Vitamin capsule filler has a hygienic configuration that allows the manufacturer to meet stringent capsule-filling guidelines. Its clean design ensures vitamin supplement safety and prevents contamination.

Boosts Productivity

Boosts Productivity with Vitamin Capsule Filler

Servo-driven motors and high-speed gadgets allow manufacturers to fill vitamin capsules at a higher rate. These automated controls boost productivity, resulting in the loading of more dosage per hour. Manufacturers prefer vitamin capsule filler to hand filler because of its higher speed and extreme filling rates.

Precise Dosing

Precise Dosing with Vitamin Capsule Filler

With the aid of weight-control systems, the vitamin capsule filler uniformly and precisely fills a combination of vitamin ingredients and other excipients inside the capsule. Weight-control systems and level sensors in the hopper monitor fill volume during capsule filling, therefore, there is no error during vitamin capsule filling.

Customization

Customization of Vitamin Capsule Filler

The modular configuration of vitamin capsule filler allows brands to adapt machines according to their capsule sizes. Moreover, this machine is easily customized to fill a variety of ingredients with its toolless disassembly.

Automation

Automation of Vitamin Capsule Filler- Picture Courtesy: PTK-GB

Modern vitamin capsule filler has technologically advanced components, with which it not only executes the functions of dosing and locking but also performs functions of capsule sorting and counting. These automated systems reduce human supervision and aid in accomplishing set targets in less time.

Optimal Quality Capsules

Optimal Quality Capsules

With its minimal human involvement, there is less chance of fill error, hence this machine outputs optimal quality capsules. Furthermore, with its high-tech mechanical and computerized systems, there is no chance of capsule and raw material wastage.

3.In What Productions Vitamin Capsule Filler is Found?

Every production that involves capsule formulation, uses the vitamin capsule filler. It increases the output rate of the production. The production applications of vitamin capsule filler are discussed below:

Nutraceutical Industry

Use of Vitamin Capsule Filler in Nutraceutical Industry- Picture Courtesy: Health Vision

Capsules are more popular for ingesting vitamin supplements because they mask the taste and smell of ingredients. For filling such an effective dosage, vitamin capsule filler is routinely employed in the nutraceutical industry. In addition to vitamins, it also fills dietary fibres, mineral supplements, probiotics, prebiotics and protein mixes in the hardgel capsules.

Pharmaceutical Industry

Use of Vitamin Capsule Filler in Pharmaceutical Industry

It is increasingly utilized in the pharmaceutical industry for dosing high-potency active ingredients, drug medications, and other therapeutic agents in capsules. It is important in the pharmaceutical industry to prevent overdosing and underdosing of the medications.

Biotechnology Industry

Use of Vitamin Capsule Filler in Biotechnology Industry- Picture Courtesy: Healthgains

In the biotechnology industry, vitamin capsule filler is utilized for filling biopharmaceuticals, biologics, hormones, and other oral vaccines. Moreover, this machine is also used for formulating temperature-stable oral capsules for test and trial purposes.

Herbal Industry

Use of Vitamin Capsule Filler in Herbal Industry- Picture Courtesy: Wikifarmer

Yes, vitamin capsule filler is employed in the herbal industry for filling herbal and Ayurvedic medication inside empty capsules. Herbal brands use vitamin capsule filler to deliver high tamping force for dosing herbal capsules.

Food Industry

Use of Vitamin Capsule Filler in Food Industry- Picture Courtesy: ConsumerLab.com

In the food industry, this machine is used for filling portion-control spice and herbal blends. It is also used for filling capsules with flavoring agents, coloring agents, and artificial sweeteners for simplifying baking and culinary preparations.

Cosmetic Industry

Use of Vitamin Capsule Filler in Cosmetic Industry- Picture Courtesy: b3engineering.com.sg

Vitamin capsule filler has a prime place in the cosmetic industry for loading various beauty products like perfumes, skin care masks, dyes, bath bombs, gels, and pastes. Its high-quality control and extremely safe operations make it popular in the cosmetic industry.

Chemical Industry

Use of Vitamin Capsule Filler in Chemical Industry- Picture Courtesy: Health

In the chemical industry, vitamin capsule filler encapsulates different high-potency chemicals, primers, and adhesives. Vitamin capsule filler is primarily utilized in the chemical industry because of its extreme accuracy and speed.

4.What are the Basic Types of the Vitamin Capsule Filler?

Vitamin capsule filler is typically classified into three major types that are discussed below:

Manual Vitamin Capsule Filler

Manual Vitamin Capsule Filler

It is a simple handheld or portable desktop vitamin capsule filler. It is a cost-effective unit, usually found in small home-based and pharmacy settings. It prepares small batches of capsules and thus has low productivity. Loading and unloading of vitamin capsules and powders is performed manually by the operators.

Some models of manual capsule filler have levers and handles to perform capsule separation as well while other models carry out just vitamin capsule filling.

Semi-automatic Vitamin Capsule Filler

Allpack Semi-automatic Vitamin Capsule Filler

This machine has a compact construction and a smaller footprint. This machine has more productivity than manual vitamin capsule filler but comes at a lower price than automatic vitamin capsule filler. It is an excellent addition for medium-sized productions that have more production needs but have budget constraints.

Vitamin capsule separation, filling, and locking are done by the machine itself while loading and unloading are carried out by the operators.

Automatic Vitamin Capsule Filler

Allpack NJP-5500C fully automatic capsule filling machine

This machine is the latest innovation in vitamin capsule filler and has technologically advanced monitoring and computerized systems that increase its output capacity. Every process from loading to unloading, filling to locking, rectification to capsule separation is carried out by the machine itself.

It has a vertical configuration and thus needs more head space. It is mostly a prominent part of the large pharmaceutical and nutraceutical industries.

5.What are Parts of Vitamin Capsule Filler?

Vitamin capsule filler consists of high-efficiency electronic, mechanical, and technological components that act consistently to carry out vitamin capsule filling. Some parts of vitamin capsule filler:

Parts of Vitamin Capsule Filler

Capsule Hopper	This conical-shaped capsule hopper stores capsules for continuous vitamin capsule-filling operations.
Safety Window	It is also known as an isolation window and its function is to separate operators from machines. It is a clear window that minimizes direct contact of operators with the machine while allowing them to view inside operation. This prevents capsule contamination.
Locking Station	The capsule bodies and caps are joined at this station after capsule filling. Cams and levers present at this station lock the halves of vitamin capsules.
Hollow Capsule Feeder	Before the vitamin capsule filling operation, the bulk quantities of empty capsules are loaded inside the hollow capsule feeder.
Vacuum Feeder	It is a feeding system that operates using a vacuum and transports the empty capsules to the filling station.
Powder Hopper	A bulk volume of vitamin powders is loaded inside the powder hopper at the start of the vitamin capsule loading operation.
Fault Alarm	It is the alarm system that automatically detects any faults, for instance, jamming, empty hoppers, etc. in the vitamin capsule filler. It sounds an alarm and lights up to notify users.
HMI Touch Screen	It is an intuitive display screen with which users program the vitamin capsule filler. Users supervise and troubleshoot equipment with this system.
Electric Cabinet	Different wires, cables, switches, and circuit breakers are housed in the sturdy electric cabinet to prevent electric and fire hazards.
Powder Filling Station	Empty capsules body travel to the powder filling station, where the required volume of vitamin powders is dispensed inside them.
Recycling Bin	In this part of the machine empty, unused, defective, and poor-quality capsules are collected.
Rejection Station	It is present at the edge of the vitamin capsule filler and consists of a rejection pin. These pins are responsible for the rejection of faulty capsules from the vitamin capsule filler.
Capsule Rectifier	It consists of a capsule loading board, horizontal fork, and vertical fork that properly orients the capsule for separation. It aligns the capsule upside down with capsule bodies facing downward.

6.What is the Working Principle of Vitamin Capsule Filler?

The components of vitamin capsule filler have their specific role in the working of vitamin capsule filler. These working stages of vitamin capsule filler are given below:

Working of Vitamin Capsule Filler

Loading of Powders and Capsules

Loading of Powders and Capsules- Picture Courtesy: Aipak

The bulk volumes of empty capsules and vitamin granules and powders are fed inside the hollow capsule feeder and powder hopper, respectively. The empty capsule via pump travels to the capsule hopper from where it moves to the capsule delivery plate. The vitamin powder travels to the capsule filling station.

Capsule Orientation

Capsule Orientation- Picture Courtesy: iPharmachine

The empty capsules must be separated into bodies and caps for the correct vitamin capsule filling. For this, capsules are deposited in the delivery plates containing numerous pockets for capsules. From these pockets, empty vitamin capsules drop down to the horizontal fork.

The latter grips the capsules around its center while the vertical fork positions the capsules in the right orientation, so the capsules' bodies are facing down.

Capsule Separation

Capsule Separation- Picture Courtesy: adalbon.is

In this step, capsule trays are moved to the separation area. The capsules are split into two halves-caps and bodies- by the vacuum divider. After separation, the capsule bodies are left in the lower capsule tray and the caps go to the upper portion of the capsule tray.

Dosing of Vitamin Materials

Dosing of Vitamin Materials-Picture Courtesy: PTK-GB

The lower capsule tray with capsule bodies is carried to the filling area. The powders from the hopper are loaded inside the empty capsule bodies. The powders are uniformly distributed inside the bodies by tamping pins.

Faulty Vitamin Capsule Rejection

Faulty Vitamin Capsule Rejection- Picture Courtesy: Smputra

Upon dosing, the defective capsules, for example, intact capsules, and dented capsules are removed from the machine using rejection pins. These pins push the vitamin capsules from molds and move them to the recycling bin.

Vitamin Capsule Closing

Vitamin Capsule Closing- Picture Courtesy: TES Equipment Supplier

Good quality vitamin capsules are closed by the overlapping of upper and lower capsule trays. During overlapping, the baffles present at the upper side of the cap tray and the pins located at the lower portion of the body tray simultaneously move to close vitamin capsules.

Capsule Ejection

Capsule Ejection- Picture Courtesy: Pharmaceutical Machinery

In the end, ejection pins push the closed vitamin capsule out of the capsule tray and the compressed air drives them to the outfeed chute.

7.What Capsules Sizes are Processed by Vitamin Capsule Filler?

Capsule Size Chart- Picture Courtesy: Capsuline

Vitamin capsule filler dose versatile capsule sizes. These capsule sizes are used for different purposes in the pharmaceutical and nutraceutical industries. There are eight capsule sizes 000, 00, 0, 1, 2, 3, 4, and 5 which are the same for both gelatin and vegetarian capsules. The details of capsule sizes are discussed below:

Capsule Size 000

It is one of the biggest capsule sizes processed by vitamin capsule filler. Its volume is 1.37 ml and its length is 26.1 mm. It encapsulates about 1000 mg of drug dose. It is widely employed for filling nutraceutical and herbal supplements.

Capsule Size 000-Picture Courtesy: CapsulCN

Capsule Size 00

It is the second largest capsule size processed by vitamin capsule filler. Its typical length is 23.4 mm and can enclose 0.9 ml of medication which is about 735 mg in weight. It is the most common capsule size and is good for holding nutraceutical supplements.

Capsule Size 00- Picture Courtesy: CapsulCN

Capsule Size 0

It is another frequently used capsule size, having a length of 21.6 ml. It can hold about 0.68 ml of vitamin powders and granules.

Capsule Size 0

Capsule Size 1

It is the smallest capsule with a length of 19.4 mm. It can enclose 0.48 ml of vitamin powders which is around 400 mg.

Capsule Size 1

Capsule Size 2

It is frequently utilized in the pharmaceutical industry but is not the preferred choice of nutraceutical brands. It has a length of 17.6 mm and its holding volume is 0.36 ml.

Capsule Size 2

Capsule Size 3

It is the smallest capsule size processed by the vitamin capsule filler. Its overall length is 15.7 mm and it can contain a dose of 0.27 ml. It is the preferred size for pediatric and elderly patients. It is also a suitable capsule size for small pets.

Capsule Size 3

Capsule Size 4

It has a length of 14.3 mm and is the second smallest capsule size processed by the vitamin capsule filler. It contains a volume of 0.2ml of medication.

Capsule Size 4- Picture Courtesy: CapsulCN

Capsule Size 5

It is the tiniest strand capsule with a length of 11.1 mm usually used in pharmaceutical industries for clinical drug trials. It holds a drug dose of 0.13ml.

Capsule Size 5-Picture Courtesy: CapsulCN

8.What Kind of Industry Standards Should the Vitamin Capsule Filler Comply With?

The vitamin capsule filler should comply with different industrial standards to ascertain the quality of filled vitamin capsules and the safety of operators. Here are some basic industrial regulations for vitamin capsule filler:

Good Manufacturing Practices

GMP- Picture Courtesy: GMP Labs

This certification is a must-have for the vitamin capsule filler. Having this certification ensures manufacturers and users that vitamin capsule filling and other manufacturing procedures in this machine fulfil the necessary safety regulations.

ISO:13485

ISO

ISO:13485- Picture Courtesy: Arena Solutions

This certification is important for the vitamin capsule filler employed in the pharmaceutical industry. It ascertains that medical devices (vitamin capsules) are consistently manufactured using the highest quality standards. It states that there is minimal possible risk associated with the usage of vitamin capsule filler.

Food and Drug Administration

FDA- Picture Courtesy: BioWorld

Compliance with FDA standards is necessary for GMP certification. This certification ensures the effectiveness and security of human and pet vitamin capsules prepared by vitamin capsule filler.

Pharmacopeial Standards

Pharmacopeial Standards- Picture Courtesy: nutraingredients-asia.com

Conformity with different pharmacopeial regulations certifies that the capsule dosing process in vitamin capsule filler is performed while adhering to quality and safety protocols.

Occupational Safety and Health Administration

OSHA Certification- Picture Courtesy: OSEA

OSHA certification is necessary for the safety of the workplace. This certification is necessary for operating the machine and ensuring the health and safety of the workforce and industrial space.

9.What are the Safety Features of Vitamin Capsule Filler?

Safety features in vitamin capsules are essential in creating optimal quality vitamin capsules and for the protection of the operator and workplace. Some of the safety features of this machine are penned below:

Safety Doors or Enclosure

Safety Doors or Enclosure- Picture Courtesy: iPharmachine

These are the clear glass panels located at the front side of the vitamin capsule filler. This is integral in protecting operators from electric shocks while the machine is running.

Emergency Stop Button

Emergency Stop Button

A red-coloured circular button is conspicuously present on the control panel of the vitamin capsule filler. Pressing this button in case of fire hazards and emergencies stops the machine quickly.

Capsule Detection Sensor

Capsule Detection Sensor

This sensor detects the presence of capsules in the filling system and stops the capsule dosing if no capsule is detected. It is important in preventing wastage of vitamin powders.

Low-Level Sensor

Low-Level Sensor

These sensors are usually present in the capsule and powder hoppers and prevent the machine from running if the materials are too low in these hoppers.

Dust Extraction Device

Dust Extraction Device

Dust generation is inevitable when vitamin capsule filling and its production during filing could spark leading to accidents; hence, dust extraction device is found in numerous vitamin capsule fillers for the safety of the workplace.

10.What are the Various Issues and their Solutions in Vitamin Capsule Filler?

Even high-tech vitamin capsule filler is bound to have unexpected issues that result in lengthy production delays. However, there are easy tips for troubleshooting them, for instance:

Capsules Separate After Locking

Splitting of Vitamin Capsule

The capsules' halves (caps and bodies) separate from each other after locking.

Cause

Overdosing of vitamin powders inside the vitamin capsules and high filling speed.

Solution

Adjust the dose fill, it should be according to the weight threshold of the vitamin capsule. Lower the fill speed.

Incorrect Vitamin Capsule Rectification

Incorrect Vitamin Capsule Rectification- Picture Courtesy: phar-machine.com

Sometimes capsules are not oriented in the right direction, causing wrong capsule separation.

Cause

When plastic containers are employed for carrying vitamin capsules, it leads to the development of electric charges that disrupt rectification

Solution

It is best to use stainless steel containers for transporting empty vitamin capsules.

Deformation of Vitamin Capsules

Deformation of Vitamin Capsules

The vitamin capsules are distorted after capsule locking.

Cause

Incorrect overlap between upper and lower capsule tray when capsules are closed.

Solution

Inspect and fix the positioning of the upper and lower capsule tray for proper overlap.

Telescoping of Vitamin Capsules

Telescoping of Vitamin Capsules- Picture Courtesy: tabletcapsules.com

Sometimes, the capsule body spills and covers a small part of the capsule cap.

Cause

Poor alignment of upper and lower capsule segments. It is also due to the large distance in the bearing system that causes poor locking of capsules.

Solution

Check and align the machine parts. Close the distance between the bearing parts for accurate alignment.

Failure in Capsule Separation

Failure in Capsule Separation

The vitamin capsule bodies and caps fail to disjoin from each other.

Cause

This can be due to incorrect vacuum settings, a dirty filter bag, poor timing of the solenoid valve, and poor alignment of the upper and lower capsule tray.

Solution

Fix the vacuum setting and it should be between 15 and 18 inches of mercury. Clean the filter bag, adjust the timing of the solenoid valve and realign the upper and lower capsule trays.

11.What are the Future Trends of Vitamin Capsule Filler?

Future Trends of Vitamin Capsule Filler- Picture Courtesy: Research and Market

The market of vitamin capsule filler is progressing day by day and it was valued at about US$ 211.32 million in 2021. It is predicted that it will grow to US$ 290.92 million in 2028 by accumulating a CAGR of 4.7%.

More and more innovations in vitamin capsule filler improve its filling capacity and accuracy. Modern vitamin capsule filler will have a weight-checking system, camera vision system, and dust control system to ensure the highest possible precision in capsule dosing.

Upcoming vitamin capsule fillers will have smart systems like enhanced sensors, IoT, and data analytics. With internet connectivity, this machine will output operational data that will be used in predicting the machine maintenance schedule. This diagnostic data will help improve machine running performance, set program parameters, and, generate optimal-quality vitamin capsules.

Conclusion

Vitamin capsule filler is needed in the pharmaceutical and nutraceutical industry because of its high productivity, automation, efficiency, precise dosing, and customization. It comes in handy for contamination-free filling of vitamin capsules. Moreover, it is equipped with the latest technology, detection sensors, and safety control systems to comply with industrial regulations and the safety of operators. Still confused or have more queries regarding vitamin capsule filler, then contact Allpack customer representatives.

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What Does Enteric Coated Mean?

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What Does Enteric Coated Mean?

Do you know that enteric coated medications are dissolved in alkaline environment like small intestine rather than an acidic environment of stomach? But the question here remains that actually what enteric coated is? Why is it applied on different types of medications? Why such types of medications are to be dissolved in intestine leaving the stomach?

Enteric Coated Fish Oil - Picture Courtesy: Omegavia

Commercially both enteric and film coated medications are manufactured depending upon their usage and application. Both of them have their own advantages. So in this guide we will be explaining in detail about enteric coated and its usage. Read it completely and get the most from it.

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1.What Does Enteric Coated Mean?

Enteric Coating Process - Picture Courtesy: iPharmachine

Stomach of a human being contains acidic substances. This acidic environment can cause irritation once specific type of capsule or tablets gets dissolved in it. To prevent this irritation and reaction with acidic environment, enteric coated is applied on pharmaceutical medications so that it remains unaffected in acidic environment and gets dissolved in basic one to get its better results.

Enteric coated is made up of Most of the times medications with enteric coated are dissolved in small intestine polyvinyl acetate phthalate, methacrylic acid copolymers and cellulose acetate phthalate like polymers that helps in blocking the reaction of those

2.What Material Are Used In Applying Enteric Coated?

Depending upon the chemical composition, materials used for enteric coated are as follows

Hydroxypropyl Methylcellulose Phthalate

Hydroxypropyl Methylcellulose Phthalate

The most commonly used polymer for enteric coating is hydroxypropyl methylcellulose phthalate. It is used due to its highly resistive nature against acid and easy solubility. Most of the medications that are taken orally are made up of HPMCP.

Cellulose Acetate Phthalate

Cellulose Acetate Phthalate

Cellulose acetate phthalate is one of the best polymers used for applying enteric coating due to its greater solubility in alkaline environment. Most of the cellulose acetate phthalate is used in medicines that show delay releasing strategy when consumed.

Polyvinyl Acetate Phthalate

Polyvinyl Acetate Phthalate

PVAP is a type of polyvinyl polymer that has same standing property like other enteric coated material. The only disadvantage in a polyvinyl acetate phthalate is that it can be applied on certain types of drugs only.

3.What Types Of Medications Uses Enteric Coated Layer?

Enteric coated are applied on various types of medications that are used for patients well being and proper treatment. Some of the medication on which enteric coated is applied are

Proton Pump Inhibitors

Omeprazole

Most of the proton pump inhibitors are used to response against the gastro esophageal reflux diseases. These require enteric coated to help them show resistance against the acidic environment of stomach and prevents from peptic ulcer condition. Aciphex, omeprazole, protonix and lansoprazole are the common examples of proton pump inhibitors that have enteric coated on their surface.

Antibiotics

Erythromycin - Picture Courtesy: Wellona Pharma

Antibiotics like erythromycin and doxycycline have enteric coated applied on them as they needs to be released in longer duration. If enteric coated is not applied on them then they will be reacted quickly in stomach and can show less effectiveness.

Anti-Inflammatory Drugs

Anti-inflammatory Tablets - Picture Courtesy: National Elf Service

Anti-inflammatory drugs are the ones that are non-steroidal in nature and can cause ulcer if released in acidic stomach. Aspirin or acetylsalicylic acid in the best example of an anti-inflammatory drugs that needs to be dissolved in intestine to reduce the chances of irritation and ulcer.

Pancreatic Medication

Enzymes - Picture Courtesy: Cystic Fibrosis WA

For proper working of pancreas and its pancreatic juices, capsules like pancrelipase have enteric coated layer to protect both throat and mouth from irritation.

Steroids

Budesonide

Budesonide and corticosteroids are some of the steroids that use enteric coated layer to minimize its side effect and prevents diseases like Crohn’s disease.

4.How Can Enteric Coated Protect The Purity Of Medication?

Enteric Coating: An Overview - Picture Courtesy: Phamaappraoch

Some of the modes in which enteric coated protects the nature of a medication are

Prevents Reaction With Gastric Acid

The most important thing for which enteric coated are preferred is that it prevents the medication to react with the gastric acid present in the stomach. As low pH values are present in the stomach, medications with greater chemical properties easily passes through the stomach without any reaction if carries enteric coated. The purity of the medication remains the same once it reaches the alkaline nature.

Allows Mature Release

Enteric coated allows delayed releasing strategy to get better effect of medication in human body. Once the medication reaches its favorable alkaline environment and gets mature duration then it gets releases to get better results.

Drug Releasing Time

Rapid Drug Release - Picture Courtesy: Evonik Health Care

It prevents from quick release of drug and allows enhancing its duration by properly maintaining the efficacy of it. Drug that require greater solubility in body are ideally to be applied with enteric coated.

Prevents Irritation

One of the most unique way to protect the medication is it does not causes any sort of irritation which travelling through the gastro esophageal channel if enteric coated is applied on it. This helps the drug to show maximum results without any side effect.

5.How Is Enteric Coated Applied?

Tablet Enteric Coating - Picture Courtesy: Springer Link

Application of enteric coated is a complete systematic process that is carried on in several uniformly arranged steps. These steps include

Initially the solution for coating is preparing that carries mixture of additives, polymers and some of the plasticizers. This coating solution is prepared in the big tank so that the mixture can be properly mixed.

In the next step, properly mixed coating solution is applied on the drugs. Medications like tablets, capsules or pills are loaded in a rotating drum and the then coating solution is sprayed on them. This process is carries in high care as uniform enteric coated is necessary in each of the drug.

In the third step, these drugs are dried under hot air stream so that the moisture or humid content can be removed from them and pure enteric coated medications can be processed.

Finally, the medications are cured in the last step where they are exposing in high temperature to make them resistive against acidic environment and get better effectiveness.

6.Is Enteric Coated Dangerous With Its Side Effects?

Drug Allergy - Picture Courtesy: Penn Medicine

Most of the enteric coated medications do not have any of the side effects as they are purely used prevent any sort of stomach ulcer or gastro esophageal irritation. The only side effect is related to the human body and its hormonal system. Individuals that are allergic to polymer substances might have potential risk of getting skin problems and some time it might be of severe condition.

Other than that if enteric coated is not applied properly it might react with the stomach acid and cause gastrointestinal irritation and nausea. Finally, few food materials can also react with the enteric coated medication that can cause harmful results so it is always better to consult with physicians before taking such medications.

7.Does Enteric Coated Helps Is Easy Absorption Of Medications In Gastrointestinal Tract?

Enteric Coated Absorption - Picture Courtesy: Science Direct

Enteric coated medications are easy to absorb in the small intestine of a gastrointestinal tract as they support in delay releasing of drug to get bet results. It prevents the body to get degradation from stomach acid acts as a barrier against low pH environment. Small intestine with basic environment easily absorbs this enteric coated medications and it’s less sensitive in nature and can easily help drug to work in an appropriate manner.

8.How Film Coated Medications Are Different From Enteric Coated?

Some of the difference between a film coated and an enteric coated medication are

Chemical Composition

Film coated usually has water soluble polymers or a thin layer of polyvinyl alcohol coated solution applied on medications.

Whereas, enteric coated medication use coating solution that is directly resistive towards acid conditions. Polymers that have low pH resistance like cellulose acetate phthalate, methacrylic acid copolymers and polyvinyl acetate phthalate are used for enteric coated.

Application

Film coated is directly applied on medications that have thin outer later and to provide them a pleasant look and easy swallowing.

Enteric coated is applied to provide protection from the acidic environment of stomach and easy dissolving in intestine.

Release Strategy

Film coated medications are dissolved quickly in the stomach and gives rapid response against the disease.

On the other hand, enteric coated medications are slow in releasing their components as they travel to gastrointestinal tract for easy absorption.

Examples

Most of the medications and drugs available have film coated layer including vitamins and pain killers.

Some unique type of antibiotics, proton pump inhibitors, anti-inflammatory drugs and steroids are the example of medications that have enteric coated layer on their surface.

9.Does Enteric Coated Cause Delay In Administrating Process Lines?

Enteric Coating - Picture Courtesy: CPHI Online

To get the therapeutic effects of any medication, intentional delays are inserted in administrating process lines while performing enteric coated. This delay is primarily inserted so that each single part of the drug can get complete enteric coated and no space should be left so that proper stability and results can be received. Similarly, the delay due to enteric coated inside the body is also to get its optimal results.

Conclusion

Enteric coated is a highly sophisticated way to prevent different types of drugs from acidic reactions. But it is always important to be familiar with what actually enteric coated is and why is it applied on medications? How is this type of coating different from film coating and what their usages are? This what does enteric coated mean gives you complete information related to enteric coated and its applications. If you still required more information regarding enteric coated and different machines involved in its process, you can contact All pack and we will guide you 24/7.

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Can you take the powder out of capsules?

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Can you take the powder out of capsules?

Have you ever found yourself staring at a capsule, wondering if you can skip it and just gulp the powder inside? The appeal of taking the powder out of capsules might seem like an awesome shortcut and a way to fast-track relief.

Before you embark on this adventure, let's discover the mysteries behind the capsule and unravel the intriguing question: Can you really take the powder out of capsules, and should you?

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1. Can you take the powder out of capsule?

Powder and Capsules - Photo Courtesy: longevitybox

The short answer to this question is yes, you can take the powder out of capsule. The process involves manually opening the capsule to access the powder inside. This process is commonly known as de-capping. There are several reasons for which you might want to take the powder out of capsule.

Difficulty Swallowing

Swallowing Capsules

Some children and elderly people may find it difficult to swallow whole capsules. It is easier for them to take the powder out of capsules and mix it with water or food instead of gulping down the capsule.

Taste Preferences

Children taste preference - Photo Courtesy: news24

Some people do not like the taste of the capsule. They find it unpleasant. Taking the powder out of capsule allows them to mix it with a appetizing substance.

Dosage Adjustment

Dose adjustment

It is also possible that some people want to adjust their dosage by taking a specific amount of the powder. This might be a result of the prescribed dose not being available in a commercially prepared form.

Immediate Absorption

Medicine Absorption - Photo Courtesy: news-medical

Another reason to take the powder out of capsule is the perception that powder has a faster absorption rate than the encapsulated form. Some might believe it will act more rapidly.

It is crucial to note that while these reasons may be motivating factors, you should exercise caution when taking the powder out of capsules.

2.Can taking the powder out of capsules be considered safe?

The safety of taking the powder out of capsules is dependent upon several factors, and a blanket answer may not apply universally. Here are some safety precautions you should consider before taking powder out of capsules.

Healthcare Provider Consultation

Healthcare consultation

Before taking the powder out of capsules, consult your healthcare provider. They can provide guidance based on your specific health condition, the type of medication, and the reasons for considering this action.

Clean Hands and Tools

Washing hands

You must ensure that your hands and any tools that you use are clean to minimize the risk of contamination.

Accurate Measurement

Accurate measurement – Photo Courtesy: askthescientists

If you are adjusting your dosage, use appropriate measuring tools to ensure accuracy. Dosing errors can occur if you estimate the dosage instead of measuring it precisely.

Monitor for Adverse Effects

Monitor Symptoms – Photo Courtesy: consultqd.clevelandclinic

Keep a close eye on your health after consuming the powder out of the capsule. If you experience any unexpected side effects or changes in your condition, contact your healthcare provider immediately.

3.Does the act of taking powder out of capsules affect the potency of the medication?

Capsule Potency

Potency of medication means the concentration or strength of the active ingredient in a drug. Capsules are designed to deliver a specific dosage with precision. There is a high likelihood that altering the form of the medication such as removing the powder out of capsule may introduce variability in the amount of active ingredient consumed by the patient.

Accurate dosing is critical for achieving the desired therapeutic effect. Capsules provide a controlled and consistent dose of medication. If you take the powder out, there is a risk of imprecise dosing, leading to underdosing or overdosing. Both scenarios can affect the overall potency and effectiveness of the medication.

However, it is also important to mention that the impact on medication effectiveness can vary depending on the specific characteristics of each drug. Some medications may be more resilient to changes in form, while others are highly dependent on the prescribed method of administration for optimal efficacy.

4.What can possibly go wrong if you take the powder out of capsule?

Taking the powder out of a capsule without proper guidance or without consulting a healthcare professional can lead to several potential issues and risks. Here are some things that can possibly go wrong if you take the powder out of capsule.

Dosage Accuracy

Dosage Accuracy

Accurate dosing is critical for the success of medical treatment. Removing the powder introduces the risk of imprecise dosing, potentially leading to underdosing or overdosing. For example, in antibiotics, underdosing could fail to eradicate the infection completely, contributing to antibiotic resistance. Overdosing poses serious health risks as well and can lead to adverse effects, toxicity, or even life-threatening complications.

Contamination Risk

Contaminated Capsule Powder Photo Courtesy: europeanpharmaceuticalreview

There is a strong risk of the powder being contaminated if it is taken out of its original capsule. It is entirely possible that the contamination occurs through contact with hands, surfaces, or other substances leading to the integrity of the medication being jeopardized.

Health Conditions

If you have a specific health condition then you may be more sensitive to changes in medication form. Certain medical conditions may warrant strict adherence to the prescribed method of administration.

Hypertension

People with heart conditions, such as hypertension rely on medications with specific dosages and formulations. Altering the form of medicine can impact blood pressure control and overall cardiovascular health.

Patients with conditions like diabetes, thyroid disorders, or adrenal insufficiency require precise medication dosing to regulate hormonal balance. Altering the form of medication may disrupt these delicate hormonal systems.

Medication Type

Different Medication Types

Some medications are engineered with a controlled-release mechanism, allowing the drug to be released gradually over an extended period. Capsules are often used for such formulations to regulate the release rate. This controlled release is vital for maintaining a consistent therapeutic level in the bloodstream and optimizing the drug's effectiveness over time.

The gastrointestinal (GI) tract, particularly the stomach, can be a harsh environment for certain medications. Some drugs are sensitive to stomach acid and digestive enzymes, which can affect their stability and efficacy. Capsules provide a protective barrier, allowing the medication to bypass the stomach and release in the intestines or other parts of the GI tract.

Taste and Palatability

Some powders inside the capsule have an unpleasant taste. Once you remove the powder from the capsule, you may expose yourself to the full flavour. This can deter you from taking the recommended dosage. This is especially true in case of young children who may fuss over the taste of the powder.

Conclusion

In the world of medicine, the simplicity of a capsule conceals a delicate balance of science. Can you take the powder out of capsules? As you have discovered that you indeed can take the powder out of capsules but it is a step not without its risks. Precision matters, formulations are intentional, and the consequences of deviation can be significant. You should remember that your health deserves nothing less than the precision and expertise that a prescribed pill encapsulates.

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What Are Medicine Capsules Made Of?

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What Are Medicine Capsules Made Of?

Have you ever wondered, the medicine capsule that you consume is exactly made up of what materials? Your curiosity is about to end here when reading ‘What are medicine capsule made of?’. The medicine capsule whether hard or soft, animal based, or plant based are made up of certain specific set of ingredients.

The manufacturing process of the medicine capsule is almost simple as the ingredients. What those ingredients could be? To deal with this mystery, let’s go for further part of the post to know more.

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1.What Is Medicine Capsule? Is Capsule Shell Used For General Action?

In medicinal terminology a medicine capsule refers to a pharmaceutical dosage form encompassing of a shell structure usually made up of collagenous nature such as gelatin or any other gelling agent. Capsule, which has small powder like, or granule sized drug substance filled into it can be delivered orally or rectally for intended use of action. They are used by pharmaceutical manufacturers to create such a drug which cannot be compacted into a tablet form or when the drug needs to be mixed with liquid additive for aiding absorption.

Capsules has many benefits over tablet dosage form. Firstly, it is easier to swallow compared to tablets and has great palatability as medicine capsules are usually manufactured as tasteless and colorless. From patient’s perspective the rate of dissolution and onset of action is much quicker than that of a tablet.

Capsules For Generalized Uses

Generally, the capsule shell is available in markets in many specifications tailored to suit different purposes. Hence, they come in many different sizes, shapes and colours. Ideally it is used more commonly in pharmaceutical and nutraceutical industries, however a capsule shell is seen to have more diversified actions.

Capsule intends to deliver lifesaving emergency drugs owing to its immediate release rate, provide multivitamins supplement, delivering essential vitamins and proteins for beauty and cosmetics industry, medicines for veterinary, fertilizer and edible baits for agricultural applications.

Strangely, technologies have advanced enough to bring out nano capsules as well, which are only about few nanometers in size but bring great advantages of it’s use. Such nano capsules are employed by agrochemicals, genetic engineering, healthcare, waste water treatment, cleaning products, cosmetics and also as tumor fighting drugs

2.What Are Types of Medicine Capsules?

Types of Medicine Capsule- Picture Courtesy: Rousselet

Medicine capsules are categorized depending upon the type of their physical structure, hard shelled or soft shelled, and upon the basis of their ingredient formulating its shell vegetable sourced or animal sourced.

Hard Shelled Capsule

Hard Gel Capsules – Picture courtesy: Capsuline

This type of capsule is constituted of a rigid covering made up of gelatinous shell or plant cellulose. It is the more commonly used medicine capsule, enclosing drug pellets or powder of fine size manufactured with the process of spheronization which are released upon reaching the target site of action. Hard shell capsules can be identified as a small body diameter that fits properly with a cap that is of larger diameter. They are made prior to be filled with the drug and so are also available as empty capsules.

Soft Shelled Capsule

Soft Gel Capsules- Picture Courtesy: Lifevision

Soft shell capsules are also composed of gelatin surrounding the liquid filled drug such as mineral and vitamin supplements or any semi solid drug. Soft gel capsules are made up of gelatin, water and opacifier along with adding of sorbitol or glycerine. Soft gelled capsules are hermetically sealed and unlike hard gelled capsules, are filled at the time of manufacturing only and they aren’t available as empty shell capsules.

Gelatinous Capsule

Gelatin for capsules formulation -Picture courtesy: Dr Axe

Gelatinous capsules as the name indicates are made incorporating gelatin solution which is the most commonly used traditional form of capsules. The ‘gelatin’ is derived from animal sources such as beef, pork, chicken or fish as well.

Hard gelled capsules are formulated using mixture of pork bone and skin or even bovine bones as it produces a tough but brittle texture. They are oftentimes used for medications and nutritional supplements as they are gluten free, tasteless and have rapid dissolution aiding easy swallowing.

Non- Gelatinous capsule

Non- gelatinous capsules

Vegetarian capsules were formulated when use of gelatin capsules had become objectionable for many of the consumers due to some religious and other cultural beliefs. Capsules were than formulated replacing gelatin as a gelling agent with those made up of plant-based sources such as hydroxypropyl methylcellulose (HPMC), pullulan, carrageenan, polyvinyl acetate (PVA) and alginate. You will read about them in further heading.

3.What Are Medicine Capsules Made Of?

Contents Of Medicine Capsule – Picture courtesy: SE Tylose

Medicinal capsules are composed by one of the two; gelatinous shell (either hard or soft) or non-gelatinous shells. These are generally formed by the hydrolysis of collagen protein which is obtained by acidic, alkaline, enzymatic, or thermal hydrolysis process extracted from an animal source or plant source.
Capsules are manufactured involving aqueous solution of gelling agents, such as animal protein (mainly gelatin) or vegetable polysaccharides or their derivatives (such as carrageenan and modified forms of starch and cellulose).

Each ingredient carries their own benefits, you’ll read them below.

Animal Based Ingredients

Animal Derived Medicinal Capsules- Picture Courtesy: Firstspot

Animal based ingredients are derived from gelatin protein, as discussed earlier, which is derived from bovine , pig or sometimes fish bones and skin. Gelatin is a miraculous substance which has been used for over several years improving physical and mental health and so being generally formulating capsules.

Plant Based Ingredients

Plant Derived Medicine Capsule

Vegetarian capsules are generally made from plant cellulose. There are different types of cellulose (starch or polysaccharide) that make up plant-based capsules. One of these materials is hypromellose. This type of cellulose is derived from coniferous trees such as pine, spruce and fir trees, or starch containing plants like tapioca root, potato etc.

HPMC Capsules

HPMC Capsules – Picture courtesy: Capsuline

HPMC Capsules are made to be vegan friendly derived from 100% plant based wood pulp , used by nutritional supplement manufacturers as it doesn’t require any additional use of fillers or binders. These capsules are tasteless, colorless and odorless and mostly people find it easier to swallow.

Pullulan Capsules

Pullulan Capsules

These capsules offer excellent plasticity and foaming properties, being derived from plant based corn starch , locust bean gum and xanthan gum , all of which being naturally occurring vegetarian sources. It can be used for encapsulating dry ingredients such as powder, pellets and herbs and specially oxygen sensitive substances as pullulan carries great oxygen barrier.

Carrageenan Capsules

Carrageenan based capsules – Picture courtesy: Vegetology

As a carbohydrate polymer based on carrageenan seaweed plant (red algae) it has also worked to replace gelatin capsules. Three types of carrageenan are employed for the making of capsules kappa, iota and lambda; however owing to it’s great gelling property kappa form is mostly used. However, this type of vegan capsule is known to have a slow disintegration rate.

PVA Capsules

PVA Capsules

PVA Capsules is another form of vegan based capsules that is into enhanced development. Polyvinyl acetate capsules have the ability to encapsulate drugs which are hydrophilic in nature or those that are insoluble and is assumed to have increased bioavailability effect.

Starch Capsules

Starch based capsules

Starch based capsules are derived from tapioca root ,potato based starch or cassava root, which are made up of hypromellose. They have great oxygen barrier property making them shelf stable and can also handle ingredients like essential oils without leakage, therefore used in dietary supplements.

4.How To Estimate Dosage Of Medicine Capsules?

Medicine capsule – picture courtesy : Nutrition insight

Estimation or calculation of exact capsule size would decide the required adequate amount of medicine to be filled inside it. Various sizes of capsules are available to suit specific needs and that would of course mean difficulty for you to choose one. But do not worry, the below presented capsule size chart will help you to find out what you need.

Size Chart

Size	Overall Capsule Length (In)	Average Mg Capacity	Volume Capacity
000	1.029	800-1600mg	1.37ml
00E	0.996	600-1200mg	0.90ml
00	0.921	600-1100mg	1.00ml
0E	0.909	462-924mg	0.78ml
0	0.85	400-800mg	0.68ml
1	0.764	300-600mg	0.48ml
2	0.693	200-400mg	0.36ml
3	0.618	162-324mg	0.27ml
4	0.563	120-240mg	0.20ml

Milligram or dose holding capsules

Size “000” can be able to contain the maximum dosage of medicine encapsulated, which is 800-1600 mg

Size “00E” has the capability to contain 600 to 1200 mg of medicinal powder. This is known to be the average sized capsule and used popularly by nutraceutical industry for it’s great filling capacity. However, ‘00’can hold 600- 1100mg.

Size “0” can hold up to 400-800 mg of drug substance. This sized capsule is employed by pharmaceutical and cosmetics industry.

Size “1” is the alternative choice for people facing difficulty in swallowing capsules as it is comparatively small in size and can hold up to 300-600 mg of drug.

Size “2” is the smaller version of size 1 capsule. However due to it’s formulation difficulty it’s less often manufactured, but still preferred. It has ability to hold 200 to 400mg of medicine.

by patients who find it difficult swallowing even the size 1 capsules.

Size “3” , size “4” and size “5” are the less common used ones, in fact only size 4 is used in dispensing pharmacy and that too in specialized cases.

Estimation Of Capsule Dosage

Dosage ordered ÷ Dosage strength × Unit of measurement = Unknown dosage (requirement)

The dosage ordered means the amount your prescriber has instructed you to take, whereas the dosage strength denotes the available dosage form (in weight) of that particular drug and the unit of measurement is the standard unit for your dosage. Calculating your capsule dosage through this formula would help you to find out what dose of medicine you require to take.

5.How do Medicine capsules dissolve in the body?

Mechanism of action of a Capsule

Medicated capsules that are enclosed in an outer shell are pharmaceutical dosage forms that are broken down in the stomach before getting transported into the bloodstream. The outer shell is broken down into digestive tract & the drug is dissolved into the bloodstream and then distributed and metabolized in much the same way as drug from a tablet.

It usually takes about 20-30 minutes for most of the drug to dissolve. When the capsule is enteric coated it protects the drug degradation from stomach acids, in case where site of action is to be reached undestroyed.

Drug molecule inside the medicine capsule affects the body by binding to multiple receptors on cells that may trigger a certain response. Although drugs are made to target particular receptors to make an intended effect, it's not possible to keep them from continuously circulating in the blood and binding to non-target sites that might be causing unwanted side effects.

Therefore, the dissolved medication moves to your liver and is then distributed to one or more target areas in your body so that it can perform its action. All over this process, the drug undergoes chemical changes, which is called as metabolism. It ultimately is expelled in your urine or feces.

Conclusion

Medicinal capsules are an intended pharmaceutical dosage form for delivery inside your body, but surprisingly they have some generalized actions too. These capsules can said to be versatile in their applications as they find it’s many purposes. Ingredients comprising these capsules are usually gelatinous or non gelatinous. They are available in different sizes as per different needs. You may take help from our given capsule size chart and dosage calculation method to solve any of your query. Still if you have any problem you can talk to our experts regarding “What Are Medicine Capsules Made Of?”. Our Allpack experts will contact you shortly.

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How To Take Half of a Capsule?

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How To Take Half of a Capsule?

Do you know why it is recommended to take capsule as whole? You always consume capsule whole with water, milk or juices. But, sometimes due to certain limitations it is not possible to take capsule as whole.

Capsule

So, how to take half of a capsule? We have designed this blog for you to discuss expert ideology about efficacy and potency of capsule activity when taking as half of it. Let’s read it to know more about capsule and its dosage administration.

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1.Why Do You Need to Administer A Half Capsule?

Capsule dose divided into half

Dosage forms like pills, tablets and capsules sometimes need to be sectioned into two halves (almost equally or equally fair) for multiple reasons. You might need to dispense half dose of a capsule for complying with patient factors, whether you’re the guardian of your patient or you yourself need to take a divided dose of your capsule. You will come to know why, after reading these factors below:

Patient Compliance

There are certain categories of patients who are unwilling to swallow capsules because of its large size and oblong shape. Geriatric or old age people find trouble in engulfing the capsule as whole and so it can be taken as half. Similarly, children or paediatric patients would have anxiety or a severe gag reflex which makes capsule swallowing difficult for them. Hence upon advise by a pharmacist the capsule can be halved to provide some ease for it to be swallowed.

Diseases

Older patients getting affected by neurological disorders such as dementia or Parkinson’s disease, xerostomia or any problem affecting their throat and oesophagus makes it harder to swallow a capsule. People facing gastrointestinal disturbance might also avoid gulping down a whole capsule as it might get stuck down their oesophagus and cause burning sensation making them feel anxious and sick.

Divided Doses

The needs of divided doses- Picture Courtesy: Hirsch Organic

Some people might want to take half of a high dose capsule to divide doses as per their healthcare provider’s instruction. Others might need to just cut down on their financial costs by keeping the remaining capsule for next dose use. Few drugs are available designed in non standard dosage, for those capsules you would require to half it down and take your prescribed amount only. However it’s very much unlikely for a capsule to be lowered into two doses, and you will read about this further in our blog.

2.How To Take Half Of A Capsule?

Transferring Capsule Content Into Water

Despite of capsules being suitable to be divided into two doses or not , interestingly one can take half of their capsules too only if they require to do so.

Taking half of a capsule is not alike taking half of a tablet. This is because of the conformational structure of a capsule varies from that of a tablet. Capsules are made up of shell closings that have two parts; the cap and the body. To open up a capsule in order to take half of it, you will need to slightly twist it open back and forth and transfer the contents, leaving behind empty shell of capsule.

The twisted open half capsule would reveal small fine granules of drug substance or a powder form of drug . Either of the both drug substance can be taken with water or sprinkled on foods or dispersed in drinks and engulfed with greater compliance.

Sprinkler capsules’ content should be mixed with soft paste like food such as yoghurt, jam, honey or fruit squash. Capsules should not be cut into divided doses with a knife or crushed by any tool, it is preferable that you purchase an inexpensive pill cutter that would be available at any pharmacy to ensure proper sectioning of drug in adequacy.

For e.g.: If you’ve 50 mg of a capsule of which you require to take 30 mg, you’ll need to disperse and dissolve the contents of capsule by mixing it vigorously in 5 ml of water and then pull via syringe or pour out 3 ml of it into a graduated medicine spoon.

You will still need to consult your pharmacist for any helpful guidelines or check the medicine label for certain advises.

3.Can You Take Half Of A Gelatin Capsule Also?

Gelatin Capsule Halved – Picture courtesy: Nutraingredients

Whether you can take half of a gelatinous capsule or not depends on the type of capsule formulation and the intended use of capsule. Type of capsule formulation such as if it is gelatin based hard shelled capsule or it is gelatin based soft capsule.
If it a hard shelled gelatinous capsule it might be able to get halved, although if it is a soft gelled capsule you won’t be able to half it actually but you may squirt out the liquid drug into a small container or spoon.

Dividing a hard shelled gelatin capsule would simply means that you’re going to twist it open and transfer half the content for dispensing. But there are certain restrictions and limitations upon which few medicines cannot be halved. Medicines like extended release capsules, enteric coated capsules and narrow therapeutic capsules should never be halved as it might result in harmful or even fatal consequences.

Although the advent of gelatinous capsules as a dosage form had eliminated quite greatly the problem of swallowing because they are smoother in texture specially when aided by a big gulp of water or milk.

4.Can Administering Half Of A Capsule Affect Efficacy?

Efficacy Of Half – Picture courtesy: Vecteezay

Capsules should not be split, crushed or opened until suggested by your medical provider. Although your pill might have a score line, you will still have to crosscheck with your pharmacist first to ensure that you can safely split it in half or not. This is because all capsules cannot be effectively halved for divided dose administration.

For instance, capsules that have a particular coating (enteric-coated pills) or those which are delivered into the body in a certain way, like extended-release (ER), sustained-release (SR) or long-acting (LA) medicines should usually not be split, cut, crushed or chewed.
This will be affecting the release properties of the drug and it’s rate of absorption too, which may cause a disastrous overdose in some cases. Then there are narrow therapeutic index drugs too which needs careful monitoring of their drug levels in your bloodstream.

Contraceptives, anti-cancer, anti-biotic, hypertensive drugs should not also be administered in half .Taking a half of any such capsule would mean that the drug would either be released too fast in your body resulting in toxic adverse effects or it would release ineffective amount or wrong dose of drug for an immediate required onset of response.
Too much of a drug will cause a toxic overdose while too little might not even give you the intended effects. Cutting a capsule would also expose your medication to environmental factors such as air, heat, and moisture, potentially making it lower in efficacy.

5.Is Taking Half Capsule Safe?

Taking Half Capsule May not be Safe- Picture Courtesy: Medication Management

Due to some reasons, it is not safe to administer half capsule. However, in some cases your healthcare provider suggests you take half capsule which is prepared under controlled conditions. Why it is not safe; you’ll be understand by reading below reasons.

You Cannot Obtain Accurate Dose

No dose accuracy- picture courtesy: business standard

As you know, capsule shell encloses specific and accurate concentrations of active ingredients and fillers. When you break or split the capsule, it may result in inaccurate dose which is not safe and not as effective as it could be.

GI Linning Irritation

Not safe for GI lining

The purpose of enclosing therapeutic active ingredients in capsule shell is to deliver safe drug at its active site without any harming GI lining. However, opening capsule shell in to half may expose interaction of drug directly over GI lining which in returns enhance the potential irritation and harm the patient.

May Worsen Your Pathology

Affects dose releasing – picture courtesy: the Guardian

Some capsules are designed to be release or disintegrate under a controlled time which is known as sustain release or extended-release product formulation. When you make them half capsule, it may disrupt the exact intended role and mechanism of action. It ultimately results in an inconsistent or rapid unwanted action.

Affects Stability

Drug Stability Issues- Picture Courtesy: Journal of Pharmaceutical

Taking half capsule may results in compromising of medicinal stability that renders no effectivity and may results in patient harm.

Conclusion

Capsules are not intended to be split, cut, crushed or chewed unless your healthcare provider has advised to do so. It also depends upon the category of drug substance it is holding and it’s type of formulation. Some capsules are of modified release dosages, some are enteric coated, and some have potentially narrow therapeutic drugs which might result in toxic effects for the patient. However splitting of capsules as per your required needs has now been generalized in many people’s mindset due to it enabling patient compliance, dose division and also in terms of cost reduction. If you’ve any questions in your mind about ‘How to take half of a Capsule’! Please message us right now, our expert will soon contact to answer your queries.

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What Is the Difference Between Capsule and Tablet?

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What Is the Difference Between Capsule and Tablet?

You have always noticed the controversy concerning efficiency and potency between capsule and tablets. Although both of these are oral solid dosage forms, but why there’s needed to develop them separately.

Capsule

Battle Between Capsule and Tablet- Picture Courtesy: GoodRx

No doubt! There are a lot of distinction between capsule and tablet; sometime tablets compete over capsule and vice versa. But you can’t ignore both in various cases. What is the difference between capsule and tablet? You’ll find in this blog post. So let’s get ready to explore.

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1.What Is the Difference Between Capsule and Tablet?

Tablet

Capsule Vs Tablet- Picture Courtesy: NOW Foods

Description

Capsule

An Enclosed Shell Offering Substances in Various States- Picture Courtesy: The Guardian

You must have administered capsule various times, which is an enclosed gelatin shell holding active substance with therapeutic or non-therapeutic actions. The external gel like structure is mainly made up of animal derived gelatin which is slowly and gradually replacing with vegan or plant derived substance that offering an elastic and gel like structure to capsule strictly following dietary restriction and preferable in many diets conscious people. So, it is catering people of different preferences with safety and flexibility.

Inside capsule, there is a broad compliance to pour either powdery, liquid, granular, beads, or any other form of substance. According to renowned pharmacist, Dr. Elizabeth Holmes, capsule is a unique structure benefits you by encasing medication belonging from various states and formulation. However, you need to keep them more protective against its interaction with air and light, you are packaging condition must be sensitive from external physical environment to sustain the efficacy and stability of active.

Tablet

A flexible dosage with compression of multiple substances and active- Picture Courtesy: Soft Gel Tech

On contrary, tablets are prepared by compression of powdered or granulated materials to form a solid formulation which is mostly composed of medication or active ingredients with other excipients which you will be reading in further section of this blog.

This is mostly known as pharmaceutical solid dosage form, known for not only its traditional applications but ensuring of stable releasing of therapeutic effects inside your body. As compared to capsule, it is not very sensitive to the external atmosphere and exhibits stable properties. Also, the preparation of tablet is flexible in the marking of score lines that allows easy splitting of the drug and easy to adjust the dose without compromising the dose integrity and dosage titration.

Pros

Capsule

Benefits of capsule- Picture Courtesy: Dallas Morning News

Capsules tend to act faster in releasing the drug because of it’s faster disintegration and offer quick ailment of symptoms.

It is Patient compliant and has great taste masking effect. Capsules are unharmful to gastrointestinal tract as they are protective against degradation by stomach acids. Capsules are made in a shell form and the medicinal powder is enclosed inside it, so they do not require the use of binders or fillers. Capsules are manufactured usually by gelatinous shells (however there are now vegetarian based capsules also available), which makes them categorized as whether they will be suitable for vegetarians or not.

Tablet

Benefits of Tablets- Picture Courtesy: Pixabay

It can also be taken by those patients who have difficulty in swallowing as tablets are also available in easy forms. Tablets can accommodate different forms of dosage according to many routes of administration (such as oral, buccal, sublingual, vaginal, rectal).

Tablets have longer shelf life and have better stability at environmental conditions. You would find tablets with easy storage offers, it is not prone to hygroscopicity and rapid degradation in open environment.

Cons

Capsule

Cons of Capsule- Picture Courtesy: MantraCare

In terms of dose division, capsule cannot be broken down into two parts and hence it is taken in a single dose only. Geriatric and paediatric patients might feel that capsules are hard to swallow because of their oblong shape, however it might not be a problem for adults. Capsules are only taken orally or rectally. Typically tablets have a better storage life rather than of capsules. Capsules are not that stable in terms of their expiry and may degrade quicker in adverse environmental conditions.

Tablet

Cons of Tablets- Picture Courtesy: VerywellHealth

The rate of disintegration of the tablet affects the bioavailability of the drug inside and has slower response rate than capsules or powders. Tablets need taste masking as it’s usually not palatable, which sometimes makes the patient unwilling to take it.

Owing to patient compliance, the tablet can be broken down and taken in divided doses because of it’s score line (the symmetrical division line on tablet surface).

Tablets are usually irritative to the gastrointestinal tract however some of them are also now enteric coated which resolves this problem.

Types

Capsule

Types of capsule- Picture Courtesy: Healthline

Capsules can be identified on their types of formulation such as whether they’re soft gelled or hard shelled or they’re constituted of plant based or animal based ingredients.

Soft Gelled:Soft gelatinous capsules are made up of gelatin and glycerine which forms the outer cover of the capsule. A liquid medicine is added inside the cover

Hard Shelled: Hard shell capsules are also made of gelatin, but they are combined with cellulose as the body part of capsule is manufactured using the former ingredient and the cap part is made using the latter one. Powdered medicinal substance is placed inside the body of capsule and enclosed by a cap

Animal Based capsule: Usually the capsules are made up of gelatin which is a product obtained by animal bones and skin ligaments. Gelatin has many health benefits and so supplement manufacturers or pharmaceutical manufacturers use this type of capsule.

Plant based capsule: Plant based capsules are intended for those vegetarians or culturally restricted people who can’t take animal based products. These capsules are HPMC or pullulan which are made from cellulose or plant parts.

Tablet

Types of tablet- Picture Courtesy: NPR

Tablets can be categorized into four of the main types, which is based on their route of administration.

Chewable Tablets: These tablets are intended to release their medicine when being chewed before swallowing. They are quickly absorbed into the stomach and have rapid onset of action. Chewable tablets are now available in many flavors.

Orally Disintegrating Tablet: Once you engulf them, they are supposed to quickly dissolve in your mouth and release their medicated ingredient. ODT is the fastest acting medicine and so it can be used for many purposes without using water for gulping it.

Sublingual Tablet: These tablets are placed beneath the tongue which gives rapid onset of action , without water for swallowing. It is used in emergency applications such a as Nitro-glycerine for angina.

Effervescent tablets: Effervescent tablets are supposed to be dissolved in water releasing bubbles in the process and they form a solution or suspension for drinking. This dosage form is constituted as decongestants, antacids or multivitamins.

Ingredients

Ingredient	Capsule	Tablet
Active Ingredients	Medicine/minerals/Vitamins	Medicine/minerals/vitamins
Binder	Lactose, Starch, Cellulose	Polymers, Gelatin, Plant Based Polymers
Shell	No External Shell	Hard and Soft Gel
Colorants	Iron Oxide and Dyes	Titanium Dioxide and Dyes

Capsule

Simple formulation & Fewer Additives- Picture Courtesy: Lipa Pharmaceuticals

This is a simple formulation as compared to tablet dosage form. That’s why this is considered as a suitable and more preferable option for the patient with allergic or intolerance problems.

Because it is considered as the most beneficial route of administration for catering people suffering digestive intolerance like lactose or gluten, sensitivity, or allergic problems.

Also, the formulation alteration and specific dietary requirement has developed new amendments and advancements as now capsules ingredients are composed of plant based formulation which making it more wider range for people with dietary restrictions.

Tablet

Mixture of Binders, fillers, & additives- Picture Courtesy: LabXchnage

Tablets on other side, often composed of various list of ingredients such as binders, fillers, and associated additives in maintain and stabilize the shape, shelf life and disintegration rate.

If you are concerned about the safety of these binders, fillers or excipients used in the tablet, then don’t worry, all additives are potentially safe for patients and their presence is essential for structural integrity and releasing of active inside the body. Means, they’re not only require for stability and shape, but it is significantly important for releasing of medicine whether controlled or sustained releasing. Thanks to additives which perform this job practically safe for you.

Methods

Capsule

With Different Shell Types- Picture Courtesy: Softgel machine

Hard shell capsules preparation: Hard shell capsules are formulated firstly by the preparation of gelatin solution ( or plant based solution) which is moved via a pumping mechanism onto the pin shaped capsule molds. These molds are made to ensure that the pins are completely immersed in that solution. Later those pins are dried in a maintained temperature and trimmed and cut into two equal or fairly equal parts (which are later identified as body and cap). The machine conjoins the both parts and is ready for filling of medicinal substance. When required to be filled the body part of the capsule is removed and drug is placed inside it in powdered form and then closed by placement of cap.

Soft gelled capsules preparation: Gelatin is first melted and then filled in the paste form in an encapsulation machine. The hopper will pour the filling material and combine the shell to shape it as a capsule. It is later placed into die cavities and gelatinous ribbons form a seal around it and then it is moved for drying process.

Tablet

Forming by Compression & Granulation- Picture Courtesy: Pharmatech

Tablets can be formulated by three kinds of strategies.

Direct Compression: Ingredients of the tablet are combined together by mixing and force is applied directly to compress it into a tablet shape. There is no need of adding any liquid binders here.

Dry Granulation: This is somewhat similar to direct compression as tablet ingredients are mixed without the addition of any liquid . Dry Granulation method is used specially when the particles of medicated ingredients are fine enough to have a restricted flow.

Wet Granulation: In this method a liquid binders is used to mix and incorporate the other medicinal ingredients and later compressed into a tablet form. Wet Granulation is also used when the particle size of powder is fine enough that it doesn’t flow.

Ease of Swallowing

Capsule

Smooth Textured & Easy to Administer- Picture Courtesy: UTIVA

Nevertheless, the smooth texture and shape of the capsule offers an easy swallowing to user. According to research, the external gelatinous make up of the capsule allowing extra palatability and offering easy ingestion in patients with difficult swallowing problems. For instance, adult or elder patient or people with oesophageal problems. According to research study conducted by Swallowing Disorders Foundation, around 67% users preferred capsules over tablets as it is very easy and smooth to ingest, so it is beneficial for those who’re facing struggle to ingest large medication.

Tablet

Versatile but Potentially Challenging- Picture Courtesy: Science Photo Library

As compared to capsule, tablets are somewhat hard to ingest in some patients. Although there are various new alteration and modifications are aided into its manufacturing that supports the swallowing. In capsule, you cannot find the way to divide the dose, but tablets are designed with score lines which helps in dose management. So if you find difficulty ingesting a large tablet; you can take divided doses.

Taste

Capsule

Best Known for Masking Unfavorable Taste- Picture Courtesy: Outsourcing Pharma

Bad taste of medicines can easily be masked if it is enclosed in a shell. The capsule acts as a barrier for drugs taste and odor, your taste buds and sense of smell won’t transmit any unwanted signal to brain. The capsule is preventing medication as well as its after-taste. So people pick them as a preferred choice as it is more palatable upon ingestion.

Tablet

Potential for Inducing Taste- Picture Courtesy: Manufacturing Chemist

By comparing to capsule, tablets may pose some unwanted challenges particularly when it comes to taste of Active Pharmaceutical Ingredients or any Active compound and excipients.

Moreover, the compression method also exposes the drug and its bitterness which contributes into the tablet. But manufacturers employed coatings and flavoring to mask undesirable taste but it sometime imparting its releasing and mechanism of action.

Absorption

Capsule

Rapid Absorption Properties- Picture Courtesy: mHealthintellegence

Capsule composed of ingredients which offering you high protection against its disintegration in the stomach or its interaction with stomach juices. This is because, medicine is degraded when enters in stomach’s acidic environment. Moreover, it is made up of external shell and internal ingredients; the purpose of this design is to keep capsule intact till it reaches intestine where alkaline pH allows its disintegration and high bioavailability. So, medications can rapidly enter the bloodstream and shows more effectiveness.

Tablet

Steady Release and Absorption- Picture Courtesy: Australian Journal of Pharma

As read above, the tablet is a compressed and a hard formulation made up of various ingredients. So, its disintegration and absorption pattern is changed than capsule. Like, some tablets are starts releasing and shows its role soon after ingesting for example, sub-lingual tablets releases and absorbs in mouth cavity.

In this way, various design alteration is implemented to control the releasing and absorption spike. Due to presence of various ingredients, the releasing of tablets takes time than capsule. Because the compressed form has to dissolution time, then upon reaching the active site, releasing excipients and active take standard time and shows it efficacy. That is why, several research studies have shown capsule absorption as fast than tablets.

Stability

Capsule

Prone to Interacting with Certain Conditions- Picture Courtesy: Fierce Pharma

Capsules are less stable and have lower integrity values than tablets. Due to hygroscopic formulation and texture stability of the capsules the can be affected by this factor. Stability may be compromised by the physical harm that capsules are prone to, such as breaking or cracking. Handling and storing substances properly are crucial.

Tablet

A Stable Solid Dosage Form- Picture Courtesy: the Pharmacist

The tablets are more stable than the capsules. Tablets are more compact and provide more resistance to moisture, so they provide more stability to the tablets. In general, tablets are more durable and less prone to physical harm. They still have the potential to chip or break, though, if the protective layer is compromised.

Shelf life

Capsule

No Extended Shelf Life- Picture Courtesy: SWK Tech

Capsules have a shorter shelf life than the tablets. So, it needs to be stored in the proper way to guarantee they do not depreciate. The shell of capsules is made up of polymers or gelatin, allowing the capsules for more exposure to oxygen contents. Since oxygen involves the degradation of particular capsules, so its decreases the shelf life of capsules. Moisture affects the stability of the medications thus leading to degradation of capsules over time, and due to the capsule shell's permeability you will need a carefully handling consideration to reduce exposure to outside influences.

Tablet

A Stable Shelf Life- Picture Courtesy: Hunter Lab

The tablet is more stable and has a long shelf life compared to capsules. Tablets are usually coated with sugar, film, or enteric. So, it protects the drugs and enhances the shelf life of tablets. Tablets are less permeable and more compact than capsules, so it does not easily affect by moisture. Due to this property, tablets sustain more shelf life compared to capsules.

2.Which is Better? Capsule or Tablet?

Which is Better- Capsule or Tablet

Justifying any one of them as better option would not be entirely appropriate, as capsules and tablets both of them have their own benefits and drawbacks. However, it can be chosen by the patient that which one seems to be a best choice for them.

Tablets have a longer shelf life but have a slow onset of action and therefore slower bioavailability while capsules act rapidly but have a very short expiry date and they are costly too. Sometimes it becomes hard to swallow a capsule or a tablet , deeming it unsuitable for patient compliance. However, it varies from patient to patients, as mostly paediatric and geriatric patients face this difficulty. Moreover, ingredients formulating a capsule such as gelatin can be problematic for those who are conservative in regards of their cultural or religious beliefs, so they would prefer a vegan option instead.

Conclusion

In a nutshell, the battle between preference of capsule over tablet or tablet over capsule goes on. It is up to the end-user and their prescribers who select the right choice of medication at appropriate situations. We hope you have enjoyed our post on ‘what is difference between capsule and tablet’. But if you have any questions, or you feel confused about any information mentioned in our blog; we would suggest you contact us right now. Allpack team member will contact soon to answer your queries.

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